Needle phobia among adult Jordanians: General awareness, prevalence; and exploring microneedles as a promising solution.

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  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
    • Abstract:
      Needle phobia remains a major drawback of conventional injectable medications, leading to avoidance and low adherence among a reasonable portion of patients. Despite this, there is a limited number of studies investigating needle phobia prevalence and symptoms. In this survey, we studied the knowledge and prevalence of needle phobia and its manifestations among 1182 adult Jordanians. Moreover, we assessed the feasibility of microneedles delivery systems as an alternative approach to conventional injectable methods. The results revealed that 28.5% of the participants identified themselves with needle phobia, with a notably higher prevalence among females compared to males (p-value < 0.001). The overall prevalence of needle phobia based on its measured manifestations was found to be 27.4%. The survey also found that 68% of the population were unfamiliar with the concept of microneedles despite the reasonable proportion of the population who were aware of the disadvantages of conventional injectable medications. Furthermore, the survey identified four significant predictors of needle phobia through hierarchical linear regression analysis. Gender, occupation, and negative past experiences with needle injections accounted for 3%, 1%, and 1% of the variance in needle phobia, respectively. In addition, the participants' preference for microneedles over conventional injectables medications appeared as another significant predictor, contributing 5% of the variance. Overall, the model explained 10% of the variance in needle phobia. Collectively, this study provides an insight into needle phobia prevalence and manifestations in Jordan, while also exploring microneedles as an alternative drug delivery system for patients with needle phobia.
      Competing Interests: The authors have declared that no competing interests exist.
      (Copyright: © 2023 Abdelghany et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
    • References:
      Clin Psychol Rev. 2006 Oct;26(6):746-68. (PMID: 16806621)
      Biomaterials. 2017 Jun;128:1-7. (PMID: 28285193)
      Psychol Assess. 2010 Mar;22(1):167-79. (PMID: 20230163)
      Vaccine. 2017 Sep 5;35(37):4896-4904. (PMID: 28780122)
      Acta Odontol Scand. 2010 Mar;68(2):98-105. (PMID: 20141364)
      J Cosmet Dermatol. 2022 Dec;21(12):7066-7074. (PMID: 36086979)
      BMC Med Res Methodol. 2022 Jul 30;22(1):209. (PMID: 35907796)
      J Am Dent Assoc. 1997 Jun;128(6):756-66. (PMID: 9188235)
      J Adv Nurs. 2019 Jan;75(1):30-42. (PMID: 30109720)
      PLoS One. 2022 Nov 21;17(11):e0276814. (PMID: 36409734)
      SAGE Open Nurs. 2018 Mar 14;4:2377960818759442. (PMID: 33415191)
      Eur J Oral Sci. 2006 Apr;114(2):122-7. (PMID: 16630303)
      Diabetes Res Clin Pract. 1999 Dec;46(3):239-46. (PMID: 10624790)
      Birth Defects Orig Artic Ser. 1984;20(6):201-7. (PMID: 6535598)
      J Anxiety Disord. 2006;20(7):946-60. (PMID: 16460906)
      Ther Deliv. 2017 Jun;8(6):447-460. (PMID: 28530151)
      J Dent Child (Chic). 2004 Sep-Dec;71(3):201-5. (PMID: 15871453)
      Aust Fam Physician. 2009 Mar;38(3):172-6. (PMID: 19283260)
      Dent Clin North Am. 2010 Oct;54(4):731-44. (PMID: 20831935)
      J Psychosom Res. 2001 Nov;51(5):665-72. (PMID: 11728507)
      Medicines (Basel). 2018 Jun 08;5(2):. (PMID: 29890643)
      Int Dent J. 2002 Feb;52(1):25-9. (PMID: 11931218)
      J Control Release. 2017 Aug 28;260:164-182. (PMID: 28549948)
      Biomed Pharmacother. 2019 Jan;109:1249-1258. (PMID: 30551375)
      Arch Dis Child. 2003 Oct;88(10):931-7. (PMID: 14500318)
      PLoS One. 2021 Jun 10;16(6):e0253048. (PMID: 34111207)
    • Subject Terms:
      Phobia, Specific
    • Publication Date:
      Date Created: 20230920 Date Completed: 20230922 Latest Revision: 20230926
    • Publication Date:
      20231215
    • Accession Number:
      PMC10511100
    • Accession Number:
      10.1371/journal.pone.0291807
    • Accession Number:
      37729191