Preoperative pregabalin prevents succinylcholine-induced fasciculation and myalgia: A meta-analysis of randomized trials.

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  • Additional Information
    • Source:
      Publisher: Elsevier España Country of Publication: Spain NLM ID: 101778594 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2341-1929 (Electronic) Linking ISSN: 23411929 NLM ISO Abbreviation: Rev Esp Anestesiol Reanim (Engl Ed) Subsets: MEDLINE
    • Publication Information:
      Original Publication: Barcelona : Elsevier España, 2015-
    • Subject Terms:
      Fasciculation*/prevention & control ; Fasciculation*/chemically induced ; Myalgia*/chemically induced ; Myalgia*/prevention & control ; Neuromuscular Depolarizing Agents*/adverse effects ; Pregabalin*/therapeutic use ; Randomized Controlled Trials as Topic* ; Succinylcholine*/adverse effects; Humans ; Analgesics/therapeutic use ; Analgesics/adverse effects ; Gabapentin/therapeutic use ; Preoperative Care/methods
    • Abstract:
      Succinylcholine is the gold standard neuromuscular blocker for rapid sequence induction; however, its use is associated with fasciculation and myalgia. We performed a systematic review and meta-analysis of randomized controlled clinical trials comparing gabapentinoids versus placebo for the prevention of fasciculations and succinylcholine-induced myalgias. Six randomized clinical studies were included with a total of 481 patients - 241 in the intervention group and 240 in the placebo group. Gabapentinoids reduced the incidence of succinylcholine-induced myalgia (RR=0.69, 95% CI 0.56-0.84, P<.001), which remained statistically significant for pregabalin (RR=0.71, 95% CI 0.54-0.93, P=.013) and gabapentin (RR=0.61, 95% CI 0.45-0.82, P=.001) separately. There was no difference in fasciculations between the groups (RR=0.92, 95% CI 0.82-1.03, P=.148). Preoperative use of gabapentinoids is associated with lower incidence of succinylcholine-induced myalgias within the first 24h of surgery.
      (Copyright © 2023. Publicado por Elsevier España, S.L.U.)
    • Contributed Indexing:
      Keywords: Fasciculaciones; Fasciculation; Gabapentin; Gabapentina; Gabapentinoides; Gabapentinoids; Mialgias; Myalgia; Pregabalin; Pregabalina; Succinilcolina; Succinylcholine
    • Accession Number:
      0 (Analgesics)
      6CW7F3G59X (Gabapentin)
      0 (Neuromuscular Depolarizing Agents)
      55JG375S6M (Pregabalin)
      J2R869A8YF (Succinylcholine)
    • Publication Date:
      Date Created: 20230906 Date Completed: 20240616 Latest Revision: 20241104
    • Publication Date:
      20241104
    • Accession Number:
      10.1016/j.redare.2022.12.002
    • Accession Number:
      37673208