Assessing antimicrobial resistance in Campylobacter jejuni and Campylobacter coli and its association with antimicrobial use in Canadian turkey flocks.

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  • Additional Information
    • Source:
      Publisher: Cambridge University Press Country of Publication: England NLM ID: 8703737 Publication Model: Electronic Cited Medium: Internet ISSN: 1469-4409 (Electronic) Linking ISSN: 09502688 NLM ISO Abbreviation: Epidemiol Infect Subsets: MEDLINE
    • Publication Information:
      Original Publication: Cambridge Eng : Cambridge University Press
    • Subject Terms:
      Campylobacter coli* ; Campylobacter jejuni* ; Anti-Infective Agents* ; Campylobacter*; Animals ; Anti-Bacterial Agents/pharmacology ; Turkeys ; Drug Resistance, Bacterial ; Macrolides ; Ontario/epidemiology ; Fluoroquinolones
    • Abstract:
      Turkeys are important sources of antimicrobial-resistant Campylobacter. A total of 1063 isolates were obtained from 293 turkey flocks across Canada between 2016 and 2021 to evaluate their antimicrobial resistance (AMR) prevalence, patterns, distribution, and association with antimicrobial use (AMU). A high proportion of C. jejuni and C. coli isolates were resistant to tetracyclines and fluoroquinolones, despite the very low use of these drugs. C. jejuni isolates had a higher probability of being resistant to tetracyclines than C. coli isolates. The chance of C. jejuni isolates being resistant to fluoroquinolones, macrolides, and lincosamides was lower compared to C. coli. Isolates from the western region had a higher probability of being resistant to fluoroquinolones than isolates from Ontario. Isolates from Ontario had higher odds of being resistant to tetracyclines than isolates from Quebec. No associations were noted between the resistance and use of the same antimicrobial, but the use of certain antimicrobial classes may have played a role in the maintenance of resistance in Campylobacter (fluoroquinolone resistance - bacitracin and streptogramin use, tetracycline resistance - flavophospholipids and streptogramins use, macrolide resistance - flavophospholipid use). Low-level multidrug-resistant Campylobacter was observed indicating a stable AMR in turkeys. This study provided insights aiding future AMU and AMR surveillance.
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    • Contributed Indexing:
      Keywords: Campylobacter coli; Campylobacter jejuni; Canada; antimicrobial resistance; antimicrobial use; fluoroquinolone; multidrug resistance; tetracycline; turkey
    • Accession Number:
      0 (Anti-Bacterial Agents)
      0 (Macrolides)
      0 (Anti-Infective Agents)
      0 (Fluoroquinolones)
    • Publication Date:
      Date Created: 20230905 Date Completed: 20230926 Latest Revision: 20231006
    • Publication Date:
      20240829
    • Accession Number:
      PMC10548540
    • Accession Number:
      10.1017/S0950268823001462
    • Accession Number:
      37667888