The relation between atherogenic index of plasma and cardiovascular outcomes in prediabetic individuals with unstable angina pectoris.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101088676 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6823 (Electronic) Linking ISSN: 14726823 NLM ISO Abbreviation: BMC Endocr Disord Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, [2001-
    • Subject Terms:
      Prediabetic State*/complications ; Atherosclerosis*/complications ; Myocardial Infarction*/complications; Humans ; Angina, Unstable/complications ; Multivariate Analysis
    • Abstract:
      Background: The atherogenic index of plasma (AIP) is a novel biomarker associated with atherosclerosis, and an important risk factor for atherosclerosis, but its relation with cardiovascular prognosis in prediabetic patients with unstable angina pectoris (UAP) is still uncertain.
      Methods: This study included 1096 prediabetic patients with UAP who were subjected to follow-up for a maximum of 30 months, with cardiac death, refractory angina, and non-fatal myocardial infarction (MI) being the primary cardiovascular endpoints.
      Results: A significantly increased AIP was observed for the group with primary cardiovascular endpoints. Kaplan-Meier curves corresponding to these endpoints revealed pronounced differences between these two AIP groups (Log-rank P < 0.001). Multivariate Cox proportional hazards analyses highlighted AIP as being independent related to this primary endpoint (HR 1.308, 95% CI: 1.213-1.412, P < 0.001). AIP addition to the baseline risk model improved the prediction of the primary endpoint (AUC: baseline model, 0.622, vs. baseline model + AIP, 0.739, P < 0.001).
      Conclusions: AIP could be used to predict cardiovascular events in prediabetic individuals with UAP.
      (© 2023. BioMed Central Ltd., part of Springer Nature.)
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    • Grant Information:
      7214223 Natural Science Foundation of Beijing, China; 7212027 Natural Science Foundation of Beijing, China; QML20210601 Beijing Hospitals Authority Youth Programme; 2017YFC0908800 National Key Research and Development Program of China; PXM2020_026272_000002 Beijing Municipal Health Commission
    • Contributed Indexing:
      Keywords: Atherogenic index of plasma; Cardiovascular outcomes; Prediabetes; Risk factor; Unstable angina pectoris
    • Publication Date:
      Date Created: 20230831 Date Completed: 20230904 Latest Revision: 20231121
    • Publication Date:
      20231215
    • Accession Number:
      PMC10469417
    • Accession Number:
      10.1186/s12902-023-01443-x
    • Accession Number:
      37653411