Restraint Stress-Induced Immunosuppression Is Associated with Concurrent Macrophage Pyroptosis Cell Death in Mice.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Pyroptosis* ; Immunosuppression Therapy*; Animals ; Mice ; Cell Death ; Macrophages ; Restraint, Physical

Psychological stress is widely acknowledged as a major contributor to immunosuppression, rendering individuals more susceptible to various diseases. The complex interplay between the nervous, endocrine, and immune systems underlies stress-induced immunosuppression. However, the underlying mechanisms of psychological-stress-induced immunosuppression remain unclear. In this study, we utilized a restraint stress mouse model known for its suitability in investigating physiological regulations during psychological stress. Comparing it with cold exposure, we observed markedly elevated levels of stress hormones corticosterone and cortisol in the plasma of mice subjected to restraint stress. Furthermore, restraint-stress-induced immunosuppression differed from the intravenous immunoglobulin-like immunosuppression observed in cold exposure, with restraint stress leading to increased macrophage cell death in the spleen. Suppression of pyroptosis through treatments of inflammasome inhibitors markedly ameliorated restraint-stress-induced spleen infiltration and pyroptosis cell death of macrophages in mice. These findings suggest that the macrophage pyroptosis associated with restraint stress may contribute to its immunosuppressive effects. These insights have implications for the development of treatments targeting stress-induced immunosuppression, emphasizing the need for further investigation into the underlying mechanisms.

Autoimmun Rev. 2022 Nov;21(11):103182. (PMID: 36028194)
Cell Mol Immunol. 2021 May;18(5):1106-1121. (PMID: 33785842)
Br J Haematol. 2022 Jan;196(2):433-437. (PMID: 34859421)
J Allergy Clin Immunol Pract. 2023 Jun;11(6):1688-1697. (PMID: 37062358)
Zhonghua Shao Shang Za Zhi. 2017 Nov 20;33(11):688-693. (PMID: 29166711)
Blood. 1994 Apr 15;83(8):2294-304. (PMID: 8161796)
Front Immunol. 2021 Mar 17;12:618577. (PMID: 33815373)
Front Pharmacol. 2023 Jun 20;14:1210393. (PMID: 37408758)
Cancers (Basel). 2020 Mar 27;12(4):. (PMID: 32230726)
Immunol Allergy Clin North Am. 2011 Feb;31(1):133-40. (PMID: 21094928)
Stem Cell Res Ther. 2021 May 6;12(1):274. (PMID: 33957977)
Front Immunol. 2021 Apr 29;12:616394. (PMID: 33995345)
Thromb Haemost. 2015 May;113(5):1060-70. (PMID: 25740324)
MedComm (2020). 2023 Apr 25;4(3):e249. (PMID: 37125240)
Psychol Bull. 2004 Jul;130(4):601-30. (PMID: 15250815)
Cell Rep. 2021 Apr 13;35(2):108979. (PMID: 33852855)
Haematologica. 2020 Feb 27;106(1):250-254. (PMID: 32107327)
AIMS Neurosci. 2022 Jan 27;9(1):57-75. (PMID: 35434276)
Sci Rep. 2016 Oct 25;6:35868. (PMID: 27779216)
Front Immunol. 2022 Apr 04;13:806686. (PMID: 35444640)
Neurosci Biobehav Rev. 1986 Fall;10(3):339-70. (PMID: 3095718)
Front Behav Neurosci. 2020 Aug 26;14:145. (PMID: 33005134)
Immunity. 2023 May 9;56(5):1046-1063.e7. (PMID: 36948194)
BJPsych Adv. 2021 May;27(3):187-197. (PMID: 34295535)
Front Cell Infect Microbiol. 2021 Oct 14;11:706849. (PMID: 34722327)
Nature. 2022 Jul;607(7919):578-584. (PMID: 35636458)
J Neuroimmunol. 1998 Dec 1;92(1-2):139-51. (PMID: 9916889)
Neurosci Biobehav Rev. 1994 Summer;18(2):223-49. (PMID: 8058215)
Cell Res. 2019 May;29(5):347-364. (PMID: 30948788)
Cells. 2021 Dec 14;10(12):. (PMID: 34944038)
PLoS One. 2010 Dec 10;5(12):e14289. (PMID: 21170330)
Curr Opin Pharmacol. 2020 Oct;54:72-81. (PMID: 32956895)
Oncotarget. 2018 Jan 30;9(16):12781-12795. (PMID: 29560109)
Braz J Psychiatry. 2013;35 Suppl 2:S101-11. (PMID: 24271222)
Front Immunol. 2018 Apr 30;9:880. (PMID: 29760702)
Blood. 2010 Dec 2;116(23):5002-9. (PMID: 20699442)
Nat Immunol. 2022 Aug;23(8):1137-1139. (PMID: 35864244)
Drug Saf. 2023 Sep;46(9):835-845. (PMID: 37378806)
Eur J Neurol. 2023 May;30(5):1417-1424. (PMID: 36779862)
Front Psychiatry. 2023 Apr 12;14:1090420. (PMID: 37124267)
J Neuroimmunol. 2008 Nov 15;204(1-2):13-9. (PMID: 18814920)
Int J Mol Sci. 2022 Jul 13;23(14):. (PMID: 35887098)
J Thromb Haemost. 2009 Feb;7(2):322-9. (PMID: 18826388)
Nanomaterials (Basel). 2016 Dec 28;7(1):. (PMID: 28336836)
J Neuroinflammation. 2022 May 24;19(1):115. (PMID: 35610721)
Int J Mol Sci. 2022 Oct 07;23(19):. (PMID: 36233211)
Front Pharmacol. 2023 Feb 22;14:1124845. (PMID: 36909184)
Allergy Asthma Clin Immunol. 2021 Oct 9;17(1):105. (PMID: 34627384)
J Vis Exp. 2015 Feb 06;(96):e52434. (PMID: 25742564)
Tzu Chi Med J. 2023 Sep 07;36(1):23-29. (PMID: 38406572)
Rev Med Virol. 2022 Nov;32(6):e2397. (PMID: 36097650)
Front Immunol. 2021 Feb 25;12:617251. (PMID: 33717109)
Int J Cancer. 2021 Jul 15;149(2):460-472. (PMID: 33751565)
Expert Rev Anti Infect Ther. 2022 Oct;20(10):1333-1340. (PMID: 35786174)
Lancet Respir Med. 2022 Feb;10(2):e15. (PMID: 35120611)
J Thromb Haemost. 2007 Nov;5(11):2291-9. (PMID: 17958746)
Immunol Rev. 2020 Sep;297(1):123-138. (PMID: 32770571)
Int J Mol Sci. 2023 Jul 01;24(13):. (PMID: 37446172)
Virulence. 2017 Oct 3;8(7):1216-1228. (PMID: 28102766)
J Blood Med. 2021 Jul 26;12:653-664. (PMID: 34345191)
Front Immunol. 2023 Jan 23;14:1116738. (PMID: 36756131)
J Int Med Res. 2022 Feb;50(2):3000605221075816. (PMID: 35196899)
Heliyon. 2023 Jul 28;9(8):e18627. (PMID: 37554775)
Sci Rep. 2015 Jul 09;5:11978. (PMID: 26156001)
Circulation. 2002 Jul 30;106(5):599-605. (PMID: 12147543)
Front Aging Neurosci. 2022 Jun 10;14:879021. (PMID: 35754962)
Neuropsychopharmacol Rep. 2020 Mar;40(1):73-84. (PMID: 31872573)
Science. 2001 Jan 19;291(5503):484-6. (PMID: 11161202)
Cells. 2023 May 31;12(11):. (PMID: 37296642)
Sci Rep. 2018 Jul 30;8(1):11447. (PMID: 30061661)
Metab Brain Dis. 2023 Aug;38(6):2065-2075. (PMID: 37148433)
Ren Fail. 2023 Dec;45(1):2149412. (PMID: 36636989)
Int J Mol Sci. 2022 Nov 18;23(22):. (PMID: 36430779)
Clin Lab. 2004;50(3-4):133-40. (PMID: 15074465)
Front Neurosci. 2023 Apr 25;17:1159929. (PMID: 37179564)
J Neuroimmunol. 2008 Feb;194(1-2):115-22. (PMID: 18192029)
Sci Rep. 2016 Sep 09;6:32935. (PMID: 27609090)
Biomedicines. 2022 Mar 03;10(3):. (PMID: 35327395)
Int J Mol Sci. 2023 May 25;24(11):. (PMID: 37298220)
SAGE Open Med Case Rep. 2021 Jun 30;9:2050313X211029699. (PMID: 34262773)
Mol Immunol. 2010 Jul;47(11-12):1974-80. (PMID: 20510456)
Front Behav Neurosci. 2014 Apr 15;8:125. (PMID: 24782732)
Nat Commun. 2019 Sep 26;10(1):4375. (PMID: 31558756)
Neurobiol Dis. 2018 Feb;110:192-205. (PMID: 29208406)
Curr Diabetes Rev. 2020;16(5):442-449. (PMID: 31657690)
Front Immunol. 2021 Jan 19;11:620339. (PMID: 33542723)
Int J Mol Sci. 2017 Dec 29;19(1):. (PMID: 29286292)
Stem Cell Res Ther. 2018 May 2;9(1):119. (PMID: 29720275)

105-2514-S-320-001-MY3, 105-2923-B-320-001-MY3, 107-2311-B-320-002 -MY3, 111-2320-B-320-006-MY3 National Science and Technology Council, Taiwan; TCMMP108-04; TCMMP 111-01;TCAS-112-02; TCAS-111-02; TCRD112-033 Tzu-Chi Medical Foundation

Keywords: ambient cold exposure; cell death; immunosuppression; intravenous immunoglobulin; macrophage; psychological stress; pyroptosis; restraint stress

Date Created: 20230826 Date Completed: 20230828 Latest Revision: 20240923

20240923

PMC10454201

10.3390/ijms241612877

37629059