A pan-cancer single-cell panorama of human natural killer cells.

Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

Publication: Cambridge, Ma : Cell Press
Original Publication: Cambridge, MIT Press.

Killer Cells, Natural*/immunology ; Neoplasms*/immunology ; Tumor Microenvironment*; Humans ; Immunity, Innate ; Immunotherapy ; Myeloid Cells ; Dendritic Cells/immunology ; Single-Cell Gene Expression Analysis

Natural killer (NK) cells play indispensable roles in innate immune responses against tumor progression. To depict their phenotypic and functional diversities in the tumor microenvironment, we perform integrative single-cell RNA sequencing analyses on NK cells from 716 patients with cancer, covering 24 cancer types. We observed heterogeneity in NK cell composition in a tumor-type-specific manner. Notably, we have identified a group of tumor-associated NK cells that are enriched in tumors, show impaired anti-tumor functions, and are associated with unfavorable prognosis and resistance to immunotherapy. Specific myeloid cell subpopulations, in particular LAMP3 ⁺ dendritic cells, appear to mediate the regulation of NK cell anti-tumor immunity. Our study provides insights into NK-cell-based cancer immunity and highlights potential clinical utilities of NK cell subsets as therapeutic targets.
Competing Interests: Declaration of interests Z.Z. is a founder of Analytical Bioscience and also serves on the Advisory Board of Cell. All financial interests are unrelated to this study.
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)

Date Created: 20230822 Date Completed: 20230920 Latest Revision: 20230920

20230921

10.1016/j.cell.2023.07.034

37607536