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Plasma AGE and Oxidation Products, Renal Function, and Preeclampsia in Pregnant Women with Type 1 Diabetes: A Prospective Observational Study.
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- Author(s): Kelly CB;Kelly CB;Kelly CB; Karanchi H; Karanchi H; Yu JY; Yu JY; Leyva MJ; Leyva MJ; Leyva MJ; Jenkins AJ; Jenkins AJ; Nankervis AJ; Nankervis AJ; Hanssen KF; Hanssen KF; Hanssen KF; Garg SK; Garg SK; Scardo JA; Scardo JA; Hammad SM; Hammad SM; Aston CE; Aston CE; Beisswenger PJ; Beisswenger PJ; Lyons TJ; Lyons TJ; Lyons TJ
- Source:
Journal of diabetes research [J Diabetes Res] 2023 Aug 10; Vol. 2023, pp. 8537693. Date of Electronic Publication: 2023 Aug 10 (Print Publication: 2023).- Publication Type:
Observational Study; Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Hindawi Limited Country of Publication: England NLM ID: 101605237 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6753 (Electronic) NLM ISO Abbreviation: J Diabetes Res Subsets: MEDLINE
- Publication Information: Publication: <2019>-: London, United Kingdom : Hindawi Limited
Original Publication: Nasr City, Cairo : Hindawi Publishing Corporation, [2013]- - Subject Terms:
- Abstract: Aims: We aimed to determine whether plasma advanced glycation end products or oxidation products (AGE/oxidation-P) predict altered renal function and/or preeclampsia (PE) in pregnant women with type 1 diabetes.
Methods: Prospectively, using a nested case-control design, we studied 47 pregnant women with type 1 diabetes, of whom 23 developed PE and 24 did not. Nineteen nondiabetic, normotensive pregnant women provided reference values. In plasma obtained at ~12, 22, and 32 weeks' gestation (visits 1, 2, and 3; V1-V3), we measured five AGE products (carboxymethyllysine (CML), carboxyethyl-lysine (CEL), methylglyoxal-hydroimidazolone (MGH1), 3-deoxyglucosone hydroimidazolone (3DGH), and glyoxal-hydroimidazolone (GH1)) and four oxidation products (methionine sulfoxide (MetSO), 2-aminoadipic acid (2-AAA), 3-nitrotyrosine (3NT), and dityrosine (DT)), by liquid chromatography/mass spectroscopy. Clinical outcomes were "estimated glomerular filtration rate" (eGFR) at each visit and onset of PE.
Results: In diabetic women, associations between AGE/oxidation-P and eGFR were found only in those who developed PE. In this group, CEL, MGH1, and GH1 at V2 and CML, CEL, MGH1, and GH1 at V3 were inversely associated with contemporaneous eGFR, while CEL, MGH1, 3DGH, and GH1 at V2 were inversely associated with eGFR at V3 (all p < 0.05). There were no associations of plasma AGE or oxidation-P with pregnancy-related development of proteinuria or PE.
Conclusions: Inverse associations of second and early third trimester plasma AGE with eGFR among type 1 diabetic women who developed PE suggest that these patients constitute a subset susceptible to AGE-mediated injury and thus to cardiorenal complications later in life. However, AGE/oxidation-P did not predict PE in type 1 diabetic women.
Competing Interests: The authors have declared that no conflict of interest exists.
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- Publication Date: Date Created: 20230821 Date Completed: 20230822 Latest Revision: 20230823
- Publication Date: 20231215
- Accession Number: PMC10435306
- Accession Number: 10.1155/2023/8537693
- Accession Number: 37601831
- Source:
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