The association between maternal body mass index and serial plasma oxytocin levels during labor.

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  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
      Obesity, Morbid* ; Labor, Obstetric*; Pregnancy ; Female ; Humans ; Oxytocin ; Body Mass Index ; Labor, Induced/methods
    • Abstract:
      Objective: To evaluate the association between maternal body mass index (BMI) and plasma oxytocin (OT) levels at different OT infusion rates in labor.
      Methods: A prospective observational study analyzing serial plasma samples in laboring women with OT infusion. The women were categorized into three groups, women with non-obesity (BMI 18.5-29.9, n = 12), obesity (BMI 30.0-34.9, n = 13), and morbid obesity (BMI ≥ 35.0, n = 15). Plasma OT was analyzed using tandem mass spectrometry.
      Results: Except for a low positive correlation between OT levels and BMI and significantly increased plasma OT levels in women with morbid obesity at the OT infusion rate of 3.3 mU/min, no significant differences in OT levels between the BMI groups were found. Further, the inter-individual differences in OT levels were large and no dose-dependent increase of OT levels was seen.
      Conclusions: Other factors than plasma OT levels may be more likely to determine the clinical response of OT infusion in women with obesity. Perhaps the observed clinical need and individual response would be a better predictor of plasma OT levels than a pre-determined OT infusion rate. The OT dosage guidelines for labor augmentation should be individualized according to clinical response rather than generalized.
      Trial Registration: Clinical trial registration: ClinicalTrials.gov ID NCT04093479.
      Competing Interests: The authors have declared that no competing interests exist.
      (Copyright: © 2023 Ramö Isgren et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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    • Molecular Sequence:
      ClinicalTrials.gov NCT04093479
    • Accession Number:
      50-56-6 (Oxytocin)
    • Publication Date:
      Date Created: 20230811 Date Completed: 20230814 Latest Revision: 20230814
    • Publication Date:
      20230814
    • Accession Number:
      PMC10420366
    • Accession Number:
      10.1371/journal.pone.0290038
    • Accession Number:
      37566578