Expression patterns of AEG-1 in the normal brain.

Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101282001 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1863-2661 (Electronic) Linking ISSN: 18632653 NLM ISO Abbreviation: Brain Struct Funct Subsets: MEDLINE

Original Publication: Berlin : Springer-Verlag, c2007-

Brain*/metabolism ; Membrane Proteins*/genetics ; Membrane Proteins*/metabolism; Animals ; Humans ; Mice ; Brain Neoplasms/pathology ; Cell Adhesion Molecules/metabolism

Astrocyte elevated gene-1 (AEG-1) is a well-known oncogene implicated in various types of human cancers, including brain tumors. Recently, AEG-1 has also been reported to play pivotal roles in glioma-associated neurodegeneration and neurodegenerative diseases like Parkinson's disease and amyotrophic lateral sclerosis. However, the normal physiological functions and expression patterns of AEG-1 in the brain are not well understood. In this study, we investigated the expression patterns of AEG-1 in the normal mouse brain and found that AEG-1 is widely expressed in neurons and neuronal precursor cells, but little in glial cells. We observed differential expression levels of AEG-1 in various brain regions, and its expression was mainly localized in the cell body of neurons rather than the nucleus. Additionally, AEG-1 was expressed in the cytoplasm of Purkinje cells in both the mouse and human cerebellum, suggesting its potential role in this brain region. These findings suggest that AEG-1 may have important functions in normal brain physiology and warrant further investigation. Our results may also shed light on the differential expression patterns of AEG-1 in normal and pathological brains, providing insights into its roles in various neurological disorders.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

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NRF-2020R1F1A1071525 National Research Foundation of Korea; NRF-2017R1D1A1B03032218 National Research Foundation of Korea

Keywords: AEG-1; Glial cells; Neurons; Normal brain

0 (Cell Adhesion Molecules)
0 (Membrane Proteins)
0 (MTDH protein, human)
0 (Mtdh protein, mouse)

Date Created: 20230708 Date Completed: 20230901 Latest Revision: 20230901

20230902

10.1007/s00429-023-02676-1

37421418