Canine models of Charcot-Marie-Tooth: MTMR2, MPZ, and SH3TC2 variants in golden retrievers with congenital hypomyelinating polyneuropathy.

Publisher: Pergamon Press Country of Publication: England NLM ID: 9111470 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2364 (Electronic) Linking ISSN: 09608966 NLM ISO Abbreviation: Neuromuscul Disord Subsets: MEDLINE

Original Publication: Oxford ; New York : Pergamon Press, c1991-

Charcot-Marie-Tooth Disease*/genetics ; Charcot-Marie-Tooth Disease*/veterinary ; Charcot-Marie-Tooth Disease*/pathology ; Polyneuropathies*/genetics ; Polyneuropathies*/veterinary; Humans ; Animals ; Dogs ; Proteins/genetics ; Heterozygote ; Alleles ; Mutation ; Protein Tyrosine Phosphatases, Non-Receptor/genetics ; Intracellular Signaling Peptides and Proteins/genetics ; Myelin P0 Protein/genetics

Congenital hypomyelinating polyneuropathy (HPN) restricted to the peripheral nervous system was reported in 1989 in two Golden Retriever (GR) littermates. Recently, four additional cases of congenital HPN in young, unrelated GRs were diagnosed via neurological examination, electrodiagnostic evaluation, and peripheral nerve pathology. Whole-genome sequencing was performed on all four GRs, and variants from each dog were compared to variants found across >1,000 other dogs, all presumably unaffected with HPN. Likely causative variants were identified for each HPN-affected GR. Two cases shared a homozygous splice donor site variant in MTMR2, with a stop codon introduced within six codons following the inclusion of the intron. One case had a heterozygous MPZ isoleucine to threonine substitution. The last case had a homozygous SH3TC2 nonsense variant predicted to truncate approximately one-half of the protein. Haplotype analysis using 524 GR established the novelty of the identified variants. Each variant occurs within genes that are associated with the human Charcot-Marie-Tooth (CMT) group of heterogeneous diseases, affecting the peripheral nervous system. Testing a large GR population (n = >200) did not identify any dogs with these variants. Although these variants are rare within the general GR population, breeders should be cautious to avoid propagating these alleles.
Competing Interests: Declaration of Competing Interest None for any authors or co-authors on “Canine models of Charcot-Marie-Tooth: MTMR2, MPZ, and SH3TC2 variants in Golden Retrievers with congenital hypomyelinating polyneuropathy” by Cook, et al. declare any conflicts of interest.
(Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)

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K01 OD027051 United States OD NIH HHS; K01 OD027058 United States OD NIH HHS

Keywords: Animal model; Dysmyelination; Electrodiagnostic testing; Genetic; Genocopies; Histopathology

0 (Proteins)
EC 3.1.3.48 (MTMR2 protein, human)
EC 3.1.3.48 (Protein Tyrosine Phosphatases, Non-Receptor)
0 (SH3TC2 protein, human)
0 (Intracellular Signaling Peptides and Proteins)
0 (MPZ protein, human)
0 (Myelin P0 Protein)

Date Created: 20230703 Date Completed: 20230831 Latest Revision: 20240802

20240802

PMC10530471

10.1016/j.nmd.2023.06.007

37400349