A proposed management classification for spinal brucellosis from India.

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  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 101230758 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-0442 (Electronic) Linking ISSN: 14778939 NLM ISO Abbreviation: Travel Med Infect Dis Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam : Elsevier Science, 2003-
    • Subject Terms:
      Brucellosis*/diagnosis ; Brucellosis*/drug therapy ; Brucellosis*/epidemiology; Humans ; Adult ; Middle Aged ; Anti-Bacterial Agents/therapeutic use ; India ; Prospective Studies
    • Abstract:
      Introduction: The myriad presentation of osteoarticular brucellosis make the patient seek the help of general practitioners, orthopaedic and rheumatology specialists. Moreover, the lack of disease-specific symptomatology is the leading cause of the delay in diagnosing osteoarticular brucellosis. Given the increasing number of spinal brucellosis cases across the country, no literature is presented on the systematic management of spinal brucellosis. However, with our experience, we formulated a classification for managing spinal brucellosis.
      Methods: A single-centred prospective observational study was conducted with 25 confirmed cases of spinal brucellosis. Patients were analysed and graded clinically, serologically, and radiologically and were managed with antibiotics for 10-12 weeks, and if necessary, stabilisation and fusion were done based on the treatment classification devised. All patients were followed up to ensure disease clearance at serial follow-up with relevant investigations.
      Results: The mean age of the study participants was 52.16 ± 12.53 years. According to spondylodiscitis severity code (SSC) grading, four patients belong to grades 1, 12 to grade 2 and 9 to grade 3 at presentation. Erythrocyte sedimentation rate (p = 0.02), c-reactive protein (p < 0.001), Brucella agglutination titers (p < 0.001), and radiological outcomes improved statistically by six months. The treatment duration was individualised according to the patient's response to the treatment, with a mean time of 11.42 ± 2.66 weeks. The mean follow-up period was 14.42 ± 8 months.
      Conclusion: High index of suspicion of patients from endemic regions, proper clinical assessment, serological evaluation, radiological assessment, appropriate decision-making (medical/surgical) in treatment, and regular follow-up were the key to successful comprehensive management of spinal brucellosis.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
    • Contributed Indexing:
      Keywords: Brucellosis; Osteoarticular; Spinal; Spondylodiscitis; Zoonosis
    • Accession Number:
      0 (Anti-Bacterial Agents)
    • Publication Date:
      Date Created: 20230701 Date Completed: 20231102 Latest Revision: 20231113
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/j.tmaid.2023.102614
    • Accession Number:
      37392982