[Increase of overdose and deaths related to methadone during COVID-19 epidemic in 2020].

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  • Additional Information
    • Transliterated Title:
      Augmentation des surdoses et décès en lien avec la consommation de méthadone durant la crise sanitaire liée au COVID-19 en 2020.
    • Source:
      Publisher: Elsevier Masson Country of Publication: France NLM ID: 0420544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1958-5578 (Electronic) Linking ISSN: 00405957 NLM ISO Abbreviation: Therapie Subsets: MEDLINE
    • Publication Information:
      Publication: 2016- : Paris : Elsevier Masson
      Original Publication: Paris : Doin
    • Subject Terms:
      COVID-19*/mortality ; COVID-19*/epidemiology ; Methadone*/poisoning ; Drug Overdose*/mortality ; Drug Overdose*/epidemiology; Humans ; France/epidemiology ; Female ; Male ; Adult ; Middle Aged ; Pharmacovigilance ; Young Adult ; Databases, Factual ; Analgesics, Opioid/poisoning ; Analgesics, Opioid/adverse effects ; Opioid-Related Disorders/epidemiology ; Opioid-Related Disorders/mortality
    • Abstract:
      Introduction: Due to the risk of overdoses increase especially with methadone, a reinforced monitoring has been set up by the French Addictovigilance Network following the first lockdown related to coronavirus disease 2019 (COVID-19). In this context, we managed a specific study to analyze overdoses related to methadone in 2020 compared to 2019.
      Material and Methods: We analyzed methadone-related overdoses which occurred in 2019 and 2020 from two sources: DRAMES program (deaths with toxicological analysis) and the French pharmacovigilance database (BNPV) (overdoses that did not lead to death).
      Results: Data from DRAMES program in 2020 show methadone as the first drug involved in deaths as well as an increase in deaths: in number (n=230 versus n=178), in proportion (41% versus 35%) and number of deaths per 1000 exposed subjects (3.4 versus 2.8). According to BNPV, the number of overdose increased in 2020 compared to 2019 (98 versus 79; i.e., 1.2-fold increase) particularly during several target periods: first lockdown, end of lockdown/summer period and second lockdown. In 2020, a higher number of cases were observed in April (n=15) and May (n=15). Overdoses and deaths occurred in subjects enrolled in treatment programs or not (naïve subjects/occasional users who obtained methadone from street market or family/friends). Overdoses resulted from different factors: overconsumption, multiple drug use with depressants drugs or cocaine, injection, consumption for sedative, recreational purposes or voluntary drug poisoning.
      Discussion/conclusion: All these data show an increase of morbidity and mortality related to methadone during COVID-19 epidemic. This trend has been observed in other countries.
      (Copyright © 2023 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved.)
    • Contributed Indexing:
      Keywords: Addictovigilance; COVID-19; Death; Décès; Methadone; Méthadone; Overdose; Surdose
    • Accession Number:
      UC6VBE7V1Z (Methadone)
      0 (Analgesics, Opioid)
    • Publication Date:
      Date Created: 20230630 Date Completed: 20240602 Latest Revision: 20240602
    • Publication Date:
      20240603
    • Accession Number:
      PMC10266982
    • Accession Number:
      10.1016/j.therap.2023.06.004
    • Accession Number:
      37391322