Bubbles Expand the Dissemination of Antibiotic Resistance in the Aquatic Environment.

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  • Additional Information
    • Source:
      Publisher: American Chemical Society Country of Publication: United States NLM ID: 0213155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5851 (Electronic) Linking ISSN: 0013936X NLM ISO Abbreviation: Environ Sci Technol Subsets: MEDLINE
    • Publication Information:
      Publication: Washington DC : American Chemical Society
      Original Publication: Easton, Pa. : American Chemical Society, c1967-
    • Subject Terms:
      Angiotensin Receptor Antagonists* ; COVID-19*; Humans ; Pandemics ; Angiotensin-Converting Enzyme Inhibitors ; Bacteria ; Drug Resistance, Microbial
    • Abstract:
      Antibiotic resistance is a global health challenge, and the COVID-19 pandemic has amplified the urgency to understand its airborne transmission. The bursting of bubbles is a fundamental phenomenon in natural and industrial processes, with the potential to encapsulate or adsorb antibiotic-resistant bacteria (ARB). However, there is no evidence to date for bubble-mediated antibiotic resistance dissemination. Here, we show that bubbles can eject abundant bacteria to the air, form stable biofilms over the air-water interface, and provide opportunities for cell-cell contact that facilitates horizontal gene transfer at and over the air-liquid interface. The extracellular matrix (ECM) on bacteria can increase bubble attachment on biofilms, increase bubble lifetime, and, thus, produce abundant small droplets. We show through single-bubble probe atomic force microscopy and molecular dynamics simulations that hydrophobic interactions with polysaccharides control how the bubble interacts with the ECM. These results highlight the importance of bubbles and its physicochemical interaction with ECM in facilitating antibiotic resistance dissemination and fulfill the framework on antibiotic resistance dissemination.
    • Contributed Indexing:
      Keywords: antibiotic resistance genes; bubble−biofilm interaction; extracellular matrix; single-bubble probe atomic force microscopy
    • Accession Number:
      0 (Angiotensin Receptor Antagonists)
      0 (Angiotensin-Converting Enzyme Inhibitors)
    • Publication Date:
      Date Created: 20230628 Date Completed: 20230712 Latest Revision: 20230718
    • Publication Date:
      20240628
    • Accession Number:
      10.1021/acs.est.3c02935
    • Accession Number:
      37379503