Antibody Phage Display Technology for Sensor-Based Virus Detection: Current Status and Future Prospects.

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    • Source:
      Publisher: MDPI Pub Country of Publication: Switzerland NLM ID: 101609191 Publication Model: Electronic Cited Medium: Internet ISSN: 2079-6374 (Electronic) Linking ISSN: 20796374 NLM ISO Abbreviation: Biosensors (Basel) Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI Pub.
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    • Abstract:
      Viruses are widespread in the environment, and many of them are major pathogens of serious plant, animal, and human diseases. The risk of pathogenicity, together with the capacity for constant mutation, emphasizes the need for measures to rapidly detect viruses. The need for highly sensitive bioanalytical methods to diagnose and monitor socially significant viral diseases has increased in the past few years. This is due, on the one hand, to the increased incidence of viral diseases in general (including the unprecedented spread of a new coronavirus infection, SARS-CoV-2), and, on the other hand, to the need to overcome the limitations of modern biomedical diagnostic methods. Phage display technology antibodies as nano-bio-engineered macromolecules can be used for sensor-based virus detection. This review analyzes the commonly used virus detection methods and approaches and shows the prospects for the use of antibodies prepared by phage display technology as sensing elements for sensor-based virus detection.
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    • Grant Information:
      22-24-00417 Russian Science Foundation
    • Contributed Indexing:
      Keywords: antibody phage display technology; biosensors; detection methods; viruses
    • Accession Number:
      0 (Antibodies)
    • Publication Date:
      Date Created: 20230627 Date Completed: 20230629 Latest Revision: 20230701
    • Publication Date:
      20231215
    • Accession Number:
      PMC10296108
    • Accession Number:
      10.3390/bios13060640
    • Accession Number:
      37367005