Robust Light Driven Enzymatic Oxyfunctionalization via Immobilization of Unspecific Peroxygenase.

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  • Additional Information
    • Source:
      Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101319536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1864-564X (Electronic) Linking ISSN: 18645631 NLM ISO Abbreviation: ChemSusChem Subsets: MEDLINE
    • Publication Information:
      Original Publication: Weinheim : Wiley-VCH
    • Subject Terms:
      Enzymes, Immobilized* ; Mixed Function Oxygenases*/chemistry ; Mixed Function Oxygenases*/metabolism; Oxidation-Reduction ; Biocatalysis
    • Abstract:
      Unspecific peroxygenases have attracted interest in synthetic chemistry, especially for the oxidative activation of C-H bonds, as they only require hydrogen peroxide (H 2 O 2 ) instead of a cofactor. Due to their instability in even small amounts of H 2 O 2 , different strategies like enzyme immobilization or in situ H 2 O 2 production have been developed to improve the stability of these enzymes. While most strategies have been studied separately, a combination of photocatalysis with immobilized enzymes was only recently reported. To show the advantages and limiting factors of immobilized enzyme in a photobiocatalytic reaction, a comparison is made between free and immobilized enzymes. Adjustment of critical parameters such as (i) enzyme and substrate concentration, (ii) illumination wavelength and (iii) light intensity results in significantly increased enzyme stabilities of the immobilized variant. Moreover, under optimized conditions a turnover number of 334,500 was reached.
      (© 2023 The Authors. ChemSusChem published by Wiley-VCH GmbH.)
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    • Grant Information:
      9063-00031B Independent Research Fund Denmark; Sapere Aude DFF Starting Grant; 764920 European Union's Horizon 2020; 1425/1-2 Deutsche Forschungsgemeinschaft
    • Contributed Indexing:
      Keywords: biocatalysis; g-C3N4; immobilized enzyme; peroxygenases; photocatalysis
    • Accession Number:
      EC 1.14.- (peroxygenase)
      0 (Enzymes, Immobilized)
      EC 1.- (Mixed Function Oxygenases)
    • Publication Date:
      Date Created: 20230625 Date Completed: 20231216 Latest Revision: 20231216
    • Publication Date:
      20231217
    • Accession Number:
      10.1002/cssc.202300613
    • Accession Number:
      37357147