Direct and indirect neurogenesis generate a mosaic of distinct glutamatergic projection neuron types in cerebral cortex.

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  • Additional Information
    • Source:
      Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE
    • Publication Information:
      Original Publication: [Cambridge, Mass. : Cell Press, c1988-
    • Subject Terms:
      Cerebral Cortex*/metabolism ; Neocortex*/physiology; Mice ; Animals ; Neurons/metabolism ; Interneurons ; Neurogenesis/physiology ; Hippocampus
    • Abstract:
      Variations in size and complexity of the cerebral cortex result from differences in neuron number and composition, rooted in evolutionary changes in direct and indirect neurogenesis (dNG and iNG) that are mediated by radial glia and intermediate progenitors (IPs), respectively. How dNG and iNG differentially contribute to neuronal number, diversity, and connectivity are unknown. Establishing a genetic fate-mapping method to differentially visualize dNG and iNG in mice, we found that while both dNG and iNG contribute to all cortical structures, iNG contributes the largest relative proportions to the hippocampus and neocortex. Within the neocortex, whereas dNG generates all major glutamatergic projection neuron (PN) classes, iNG differentially amplifies and diversifies PNs within each class; the two pathways generate distinct PN types and assemble fine mosaics of lineage-based cortical subnetworks. Our results establish a ground-level lineage framework for understanding cortical development and evolution by linking foundational progenitor types and neurogenic pathways to PN types.
      Competing Interests: Declaration of interests The authors declare no competing interests.
      (Copyright © 2023 Elsevier Inc. All rights reserved.)
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    • Grant Information:
      DP1 MH129954 United States MH NIMH NIH HHS; F30 MH108333 United States MH NIMH NIH HHS; F32 NS096877 United States NS NINDS NIH HHS; U19 MH114821 United States MH NIMH NIH HHS
    • Contributed Indexing:
      Keywords: PyNs; dNG; direct neurogenesis; fate mapping; iNG; indirect neurogenesis; neocortex; pallium; pyramidal neurons
    • Publication Date:
      Date Created: 20230622 Date Completed: 20230821 Latest Revision: 20240817
    • Publication Date:
      20240817
    • Accession Number:
      PMC10527425
    • Accession Number:
      10.1016/j.neuron.2023.05.021
    • Accession Number:
      37348506