Clinical features of newly diagnosed systemic lupus erythematosus after SARS-CoV-2 vaccination.

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  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 101761026 Publication Model: Print Cited Medium: Internet ISSN: 2472-5625 (Electronic) Linking ISSN: 24725625 NLM ISO Abbreviation: Mod Rheumatol Case Rep Subsets: MEDLINE
    • Publication Information:
      Publication: 2021- : Oxford : Oxford University Press
      Original Publication: Abingdon, Oxfordshire : Taylor & Francis, [2017]-
    • Subject Terms:
      Autoimmune Diseases* ; COVID-19*/diagnosis ; COVID-19*/prevention & control ; COVID-19 Vaccines*/adverse effects ; Lupus Erythematosus, Systemic*/complications ; Lupus Erythematosus, Systemic*/diagnosis; Humans ; Male ; Middle Aged ; SARS-CoV-2 ; Vaccination/adverse effects
    • Abstract:
      Systemic lupus erythematosus (SLE) is an autoimmune disease that causes damage to multiple organs. Various factors, including vaccination, have been associated with SLE development. Vaccination for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in 2020, and there are a few reports on the exacerbation of SLE after SARS-CoV-2 vaccination. The influence of SARS-CoV-2 vaccination on SLE development remains unclear. We present the case of a 53-year-old man who developed peritonitis and was subsequently diagnosed with SLE on Day 9 after receiving a third dose of the messenger ribonucleic acid-1273 SARS-CoV-2 vaccine. This case and previous reports have shown that patients who developed SLE after SARS-CoV-2 vaccination are more likely to develop it within 2 weeks of vaccination, especially when they have a higher rate of immunological abnormalities or a family history of autoimmune diseases. Furthermore, these features suggest that type I interferon is involved in the pathogenesis of SLE after SARS-CoV-2 vaccination.
      (© Japan College of Rheumatology 2023. Published by Oxford University Press.)
    • Contributed Indexing:
      Keywords: COVID-19; SARS-CoV-2; Systemic lupus erythematosus; interferon type I; vaccination
    • Accession Number:
      0 (COVID-19 Vaccines)
    • Publication Date:
      Date Created: 20230622 Date Completed: 20240103 Latest Revision: 20240103
    • Publication Date:
      20240104
    • Accession Number:
      10.1093/mrcr/rxad036
    • Accession Number:
      37348045