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Seroprevalence and clinical characteristics of SARS-CoV-2 infection in children with cystic fibrosis.
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- Author(s): Hergenroeder GE;Hergenroeder GE;Hergenroeder GE; Faino AV; Faino AV; Cogen JD; Cogen JD; Cogen JD; Cogen JD; Genatossio A; Genatossio A; McNamara S; McNamara S; Pascual M; Pascual M; Hernandez RE; Hernandez RE; Hernandez RE; Hernandez RE
- Source:
Pediatric pulmonology [Pediatr Pulmonol] 2023 Sep; Vol. 58 (9), pp. 2478-2486. Date of Electronic Publication: 2023 Jun 14.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural- Language:
English - Source:
- Additional Information
- Source: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8510590 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0496 (Electronic) Linking ISSN: 10990496 NLM ISO Abbreviation: Pediatr Pulmonol Subsets: MEDLINE
- Publication Information: Publication: <2005-> : Hoboken, NJ : Wiley-Liss
Original Publication: [Philadelphia, PA] : W.B. Saunders, [c1985- - Subject Terms:
- Abstract: Background: People with cystic fibrosis (PwCF) have chronic lung disease and may be at increased risk of coronavirus disease 2019 (COVID-19)-related morbidity and mortality. This study aimed to determine seroprevalence and clinical characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children with cystic fibrosis (CF), and to assess antibody responses following SARS-CoV-2 infection or vaccination.
Methods: Children and adolescents with CF followed at Seattle Children's Hospital were enrolled between July 20, 2020 and February 28, 2021. SARS-CoV-2 serostatus was determined on enrollment at 6 and 11 months (±2 months) for nucleocapsid and spike IgG. Participants completed intake and weekly surveys inquiring about SARS-CoV-2 exposures, viral/respiratory illnesses, and symptoms.
Results: Of 125 PwCF enrolled, 14 (11%) had positive SARS-CoV-2 antibodies consistent with recent or past infection. Seropositive participants were more likely to identify as Hispanic (29% vs. 8%, p = 0.04) and have pulmonary exacerbations requiring oral antibiotics in the year prior (71% vs. 41%, p = 0.04). Five seropositive individuals (35.7%) were asymptomatic, while six (42.9%) reported mild symptoms, primarily cough and nasal congestion. Antispike protein IgG levels were approximately 10-fold higher in participants following vaccination compared with participants who had natural infection alone (p < 0.0001) and resembled levels previously reported in the general population.
Conclusions: A majority of PwCF have mild or no symptoms of SARS-CoV-2 making it difficult to distinguish from baseline respiratory symptoms. Hispanic PwCF may be disproportionately impacted, consistent with racial and ethnic COVID-19 disparities among the general US population. Vaccination in PwCF generated antibody responses similar to those previously reported in the general population.
(© 2023 Wiley Periodicals LLC.) - References: Holshue ML, DeBolt C, Lindquist S, et al. First case of 2019 novel coronavirus in the United States. N Engl J Med. 2020;382(10):929-936.
Centers for Disease Control and Prevention. CDC COVID Data Tracker Atlanta, GA: US Department of Health and Human Services. https://covid.cdc.gov/covid-data-tracker.
Moeller A, Thanikkel L, Duijts L, et al. COVID-19 in children with underlying chronic respiratory diseases: survey results from 174 centres. ERJ Open Res. 2020;6(4):00409-2020.
Bialek S, Gierke R, Hughes M, McNamara LA, Pilishvili T, Skoff T, CDC COVID-19 Response Team. Coronavirus disease 2019 in children-United States, February 12-April 2, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(14):422-426.
Shteinberg M, Haq IJ, Polineni D, Davies JC. Cystic fibrosis. Lancet. 2021;397(10290):2195-2211.
McClenaghan E, Cosgriff R, Brownlee K, et al. The global impact of SARS-CoV-2 in 181 people with cystic fibrosis. J Cyst Fibros. 2020;19(6):868-871.
Bain R, Cosgriff R, Zampoli M, et al. Clinical characteristics of SARS-CoV-2 infection in children with cystic fibrosis: an international observational study. J Cyst Fibros. 2021;20(1):25-30.
Carr SB, McClenaghan E, Elbert A, et al. Factors associated with clinical progression to severe COVID-19 in people with cystic fibrosis: a global observational study. J Cyst Fibros. 2022;21(4):e221-e231.
Wiegand RE, Deng Y, Deng X, et al. Estimated SARS-CoV-2 antibody seroprevalence trends and relationship to reported case prevalence from a repeated, cross-sectional study in the 50 states and the District of Columbia, United States-October 25, 2020-February 26, 2022. Lancet Reg Health Am. 2023;18:100403.
Berardis S, Verroken A, Vetillart A, et al. SARS-CoV-2 seroprevalence in a Belgian cohort of patients with cystic fibrosis. J Cyst Fibros. 2020;19(6):872-874.
Alicandro G, Daccó V, Cariani L, et al. SARS-CoV-2 antibodies among people with cystic fibrosis prior to the vaccination campaign: a seroprevalence study in two specialized centres in Northern Italy. J Cyst Fibros. 2022;21(2):e113-e116.
Jaudszus A, Pavlova M, Rasche M, Baier M, Moeser A, Lorenz M. One year monitoring of SARS-CoV-2 prevalence in a German cohort of patients with cystic fibrosis. BMC Pulm Med. 2022;22(1):101.
Browning MJ, Lim MTC, Kenia P, et al. Pneumococcal polysaccharide vaccine responses are impaired in a subgroup of children with cystic fibrosis. J Cyst Fibros. 2014;13(6):632-638.
Launay O, Boelle PY, Krivine A, et al. Factors associated with humoral immune response to pandemic A/H1N1(v) 2009 influenza vaccine in cystic fibrosis. Vaccine. 2014;32(35):4515-4521.
Moss RB, Hsu YP, Van Bude PH, Van Leeuwen AM, Lewiston NJ, Lange GD. Altered antibody isotype in cystic fibrosis: impaired natural antibody response to polysaccharide antigens. Pediatr Res. 1987;22(6):708-713.
Harris PA, Taylor R, Minor BL, et al. The REDCap consortium: building an international community of software platform partners. J Biomed Inf. 2019;95:103208.
Barouch DH. Covid-19 vaccines-immunity, variants, boosters. N Engl J Med. 2022;387(11):1011-1020.
Food and Drug Administration. EUA Authorized Serology Test Performance: US Department of Health and Human Services, Food and Drug Administration; 2023. updated Aug 22, 2022. https://www.fda.gov/medical-devices/coronavirus-disease-2019-covid-19-emergency-use-authorizations-medical-devices/eua-authorized-serology-test-performance.
Bryan A, Pepper G, Wener MH, et al. Performance characteristics of the abbott architect SARS-CoV-2 IgG assay and seroprevalence in Boise, Idaho. J Clin Microbiol. 2020;58(8):e00941-20. doi:10.1128/JCM.00941-20.
Perkmann T, Perkmann-Nagele N, Koller T, et al. Anti-spike protein assays to determine SARS-CoV-2 antibody levels: a head-to-head comparison of five quantitative assays. Microbiol Spectr. 2021;9(1):e0024721.
Bajema KL, Wiegand RE, Cuffe K, et al. Estimated SARS-CoV-2 seroprevalence in the US as of September 2020. JAMA Intern Med. 2021;181(4):450-460.
Clarke KEN, Jones JM, Deng Y, et al. Seroprevalence of Infection-Induced SARS-CoV-2 antibodies-United States, September 2021-February 2022. MMWR Morb Mortal Wkly Rep. 2022;71(17):606-608.
Takahashi S, Peluso MJ, Hakim J, et al. SARS-CoV-2 serology across scales: a framework for unbiased estimation of cumulative incidence incorporating antibody kinetics and epidemic recency. Am J Epidemiol. Published online April 29, 2023. doi:10.1093/aje/kwad106.
Centers for Disease Control and Prevention. Risk for Covid-19 Infection, Hospitalization, and Death By Race/Ethnicity Atlanta, GA: US Department of Health and Human Serveces, CDC; 2022. updated Dec 28, 2022 Available from: https://www.cdc.gov/coronavirus/2019-ncov/covid-data/investigations-discovery/hospitalization-death-by-race-ethnicity.html.
Ripperger TJ, Uhrlaub JL, Watanabe M, et al. Orthogonal SARS-CoV-2 serological assays enable surveillance of low-prevalence communities and reveal durable humoral immunity. Immunity. 2020;53(5):925-933.e4.
Krutikov M, Palmer T, Tut G, et al. Prevalence and duration of detectable SARS-CoV-2 nucleocapsid antibodies in staff and residents of long-term care facilities over the first year of the pandemic (VIVALDI study): prospective cohort study in England. Lancet Healthy Longev. 2022;3(1):e13-e21.
Wei J, Pouwels KB, Stoesser N, et al. Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines. Nat Med. 2022;28(5):1072-1082.
Doria-Rose N, Suthar MS, Makowski M, et al. Antibody persistence through 6 months after the second dose of mRNA-1273 vaccine for Covid-19. N Engl J Med. 2021;384(23):2259-2261.
Alicandro G, Daccò V, Cariani L, et al. Immunogenicity of BNT162b2 mRNA-based vaccine against SARS-CoV-2 in people with cystic fibrosis according to disease characteristics and maintenance therapies. Biomedicines. 2022;10(8):1998.
Lambrou AS, Shirk P, Steele MK, et al. Genomic surveillance for SARS-CoV-2 variants: predominance of the delta (B.1.617.2) and omicron (B.1.1.529) variants-United States, June 2021-January 2022. MMWR Morb Mortal Wkly Rep. 2022;71(6):206-211. - Grant Information: UL1 TR002319 United States TR NCATS NIH HHS
- Contributed Indexing: Keywords: COVID-19; SARS-CoV-2; antibodies; cystic fibrosis; patient symptoms; seroprevalence
- Accession Number: 0 (Immunoglobulin G)
- Publication Date: Date Created: 20230614 Date Completed: 20230821 Latest Revision: 20230821
- Publication Date: 20230822
- Accession Number: 10.1002/ppul.26528
- Accession Number: 37314149
- Source:
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