Effect of Late-Stage Meniere's Disease and Vestibular Functional Impairment on Hippocampal Atrophy.

Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 8607378 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-4995 (Electronic) Linking ISSN: 0023852X NLM ISO Abbreviation: Laryngoscope Subsets: MEDLINE

Publication: <2009- >: Philadelphia, PA : Wiley-Blackwell
Original Publication: St. Louis, Mo. : [s.n., 1896-

Meniere Disease*/complications ; Meniere Disease*/diagnostic imaging ; Endolymphatic Hydrops*/diagnostic imaging ; Endolymphatic Hydrops*/complications ; Vestibule, Labyrinth*/diagnostic imaging; Male ; Female ; Humans ; Adult ; Middle Aged ; Vertigo/complications ; Atrophy/complications ; Hippocampus/diagnostic imaging ; Hippocampus/pathology ; Magnetic Resonance Imaging/methods

Objective: We investigated correlations among clinical features, degree of inner ear endolymphatic hydrops (EH), and hippocampal volume (HV) in different stages of Meniere's disease (MD).
Methods: From February 2021 to April 2022, clinical data were collected from 99 patients (39 males, 60 females, mean age: 50.4 ± 10.0 [range: 26-69] years) with unilateral MD admitted to the Department of Vertigo Disease of Shandong ENT Hospital. The left and right ears were affected in 64 and 35 patients, respectively. There were 50 and 49 cases in early (Stages 1, 2) and late stages (Stages 3, 4), respectively. Fifty healthy participants were included as controls. Audiovestibular function test results, EH grading using gadolinium-enhanced magnetic resonance imaging (MRI), and HV determined on MRI were analyzed for patients at different stages of MD.
Results: Between-group comparisons of early and late MD revealed significant differences in the disease course, vestibular function (VF), degree of EH, and HV. There were no significant between-group differences based on age, sex, affected side, subjective degree of dizziness, hospital anxiety, or depression. Mean HV in patients with early-stage MD was correlated with the canal paresis value of the caloric test and pure tone hearing threshold, HV in late-stage patients was correlated with vestibular EH.
Conclusion: Patients with late-stage MD exhibited severe auditory and VF impairments, increased EH, and atrophy of the HV. More advanced disease was associated with greater vestibular damage and degree of EH.
Level of Evidence: 3 Laryngoscope, 134:410-418, 2024.
(© 2023 The American Laryngological, Rhinological and Otological Society, Inc.)

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82271172 National Natural Science Foundation of China; 82171150 National Natural Science Foundation of China; 82196821 the Major Program of National Natural Science Foundation of China; ZR2021ZD40 the Major Fundamental Research Program of the Natural Science Foundation of Shandong Province, China; ts20130913 the Taishan Scholars Program of Shandong Province; ZR2020MH179 the Shandong Provincial Natural Science Foundation; 202009011528 the Medical and Health Science and Technology Development Program of Shandong Province; 202009010992 the Medical and Health Science and Technology Development Program of Shandong Province

Keywords: Meniere's disease; endolymphatic hydrops; hippocampus; inner ear disease; vestibular impairment

Date Created: 20230614 Date Completed: 20231226 Latest Revision: 20240703

20240703

10.1002/lary.30816

37314111