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Overview of autoantibodies in COVID-19 convalescents.
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- Author(s): Dobrowolska K;Dobrowolska K; Zarębska-Michaluk D; Zarębska-Michaluk D; Poniedziałek B; Poniedziałek B; Jaroszewicz J; Jaroszewicz J; Flisiak R; Flisiak R; Rzymski P; Rzymski P
- Source:
Journal of medical virology [J Med Virol] 2023 Jun; Vol. 95 (6), pp. e28864.- Publication Type:
Journal Article; Review- Language:
English - Source:
- Additional Information
- Source: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE
- Publication Information: Publication: New York Ny : Wiley-Liss
Original Publication: New York, Liss. - Subject Terms:
- Abstract: Accumulating evidence shows that SARS-CoV-2 can potentially trigger autoimmune processes, which can be responsible for the long-term consequences of COVID-19. Therefore, this paper aims to review the autoantibodies reported in COVID-19 convalescents. Six main groups were distinguished: (i) autoantibodies against components of the immune system, (ii) autoantibodies against components of the cardiovascular system, (iii) thyroid autoantibodies, (iv) autoantibodies specific for rheumatoid diseases, (v) antibodies against G-protein coupled receptors, and (vi) other autoantibodies. The evidence reviewed here clearly highlights that SARS-CoV-2 infection may induce humoral autoimmune responses. However, the available studies share number of limitations, such as: (1) the sole presence of autoantibodies does not necessarily implicate the clinically-relevant risks, (2) functional investigations were rarely performed and it is often unknown whether observed autoantibodies are pathogenic, (3) the control seroprevalence, in healthy, noninfected individuals was often not reported; thus it is sometimes unknown whether the detected autoantibodies are the result of SARS-CoV-2 infection or the accidental post-COVID-19 detection, (4) the presence of autoantibodies was rarely correlated with symptoms of the post-COVID-19 syndrome, (5) the size of the studied groups were often small, (6) the studies focused predominantly on adult populations, (7) age- and sex-related differences in seroprevalence of autoantibodies were rarely explored, (8) genetic predispositions that may be involved in generation of autoantibodies during SARS-CoV-2 infections were not investigated, and (9) the autoimmune reactions following infection with SARS-CoV-2 variants that vary in the clinical course of infection remain unexplored. Further longitudinal studies are advocated to assess the link between identified autoantibodies and particular clinical outcomes in COVID-19 convalescents.
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- Accession Number: 0 (Autoantibodies)
0 (Blood Group Antigens) - Subject Terms: SARS-CoV-2 variants
- Publication Date: Date Created: 20230613 Date Completed: 20230615 Latest Revision: 20230625
- Publication Date: 20231215
- Accession Number: 10.1002/jmv.28864
- Accession Number: 37310140
- Source:
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