A case of metformin-associated lactic acidosis with cardiogenic and vasoplegic shock supported by ECPella.

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  • Author(s): Ling SK;Ling SK; Chung KW; Chung KW; Ma HY; Ma HY
  • Source:
    Perfusion [Perfusion] 2024 Sep; Vol. 39 (6), pp. 1265-1269. Date of Electronic Publication: 2023 Jun 05.
  • Publication Type:
    Case Reports; Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: SAGE Publications Country of Publication: England NLM ID: 8700166 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-111X (Electronic) Linking ISSN: 02676591 NLM ISO Abbreviation: Perfusion Subsets: MEDLINE
    • Publication Information:
      Publication: London : SAGE Publications
      Original Publication: [London] : Edward Arnold, [c1986-
    • Subject Terms:
      Acidosis, Lactic*/chemically induced ; Acidosis, Lactic*/therapy ; Metformin*/adverse effects ; Metformin*/therapeutic use ; Shock, Cardiogenic*/chemically induced ; Shock, Cardiogenic*/therapy ; Extracorporeal Membrane Oxygenation*/methods; Humans ; Vasoplegia/drug therapy ; Male ; Female ; Middle Aged
    • Abstract:
      Metfomin-associated lactic acidosis (MALA) is a rare but life-threatening complication of metformin use. We present a case of MALA with concurrent cardiogenic and vasoplegic shock which was successfully supported by ECPella (concurrent use of VA-ECMO and Impella). Early recognition, aggressive hemodynamic support with ECPella and early hemodialysis can be life-saving. Monitoring of both lactate and S v O 2 trends can help understand the response to treatment.
      Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
    • Contributed Indexing:
      Keywords: ecpella; impella;; mala; metfomin-associated lactic acidosis;; metformin;; va-ecmo;
    • Accession Number:
      9100L32L2N (Metformin)
    • Publication Date:
      Date Created: 20230605 Date Completed: 20240926 Latest Revision: 20241122
    • Publication Date:
      20241122
    • Accession Number:
      10.1177/02676591231181851
    • Accession Number:
      37272660