Spontaneous Regression of Ossifying Fibroma in the Oral and Maxillofacial Region: A Rare Case With 4-Year Follow-Up.

Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9010410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-3732 (Electronic) Linking ISSN: 10492275 NLM ISO Abbreviation: J Craniofac Surg

Publication: <2014-> : Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: Burlington, Ont. : B.C. Decker, c1990-

Fibroma, Ossifying*/diagnostic imaging ; Fibroma, Ossifying*/surgery ; Skull Neoplasms*/pathology; Male ; Humans ; Child ; Follow-Up Studies ; Maxilla/surgery ; Head/pathology

The case presented in this study is a rare instance of an ossifying fibroma (OF), a type of benign fibro-osseous lesions, spontaneously regressed without surgical intervention. A 9-year-old boy with an intraosseous lesion in the left maxilla was diagnosed as OF. The surgeon suggested surgical excision, but due to personal reasons, the patient and his parents deferred the surgery and opted for regular follow-up. During a 4-year follow-up, the surgeon found that the lesion had significantly decreased in size and the facial deformity had remitted. At the latest follow-up, the deformity of his left face became almost unnoticeable, and the lesion seemed to be subtle on cone-beam computed tomography images. This case highlights the possibility of spontaneous regression of OF. This phenomenon may occur due to the teeth eruption, which can lead to the formation of periodontal ligaments and engage the regression of OF.
Competing Interests: The authors report no conflicts of interest.
(Copyright © 2023 by Mutaz B. Habal, MD.)

El-Mofty SK. Fibro-osseous lesions of the craniofacial skeleton: an update. Head Neck Pathol 2014;8:432–444.
El-Mofty SK, Nelson B, Toyosawa S, et al. El-Naggar A, Chan J, Grandis J, Takata T, Slootweg P. Ossifying fibroma. WHO Classification of Head and Neck Tumours, 4th edns. Chapter 8. Lyon: International Agency for Research on Cancer (IARC) Press; 2017:251–252.
MacDonald-Jankowski DS. Ossifying fibroma: a systematic review. Dentomaxillofac Radiol 2009;38:495–513.
Soluk-Tekkesin M, Sinanoglu A, Selvi F, et al. The importance of clinical and radiological findings for the definitive histopathologic diagnosis of benign fibro-osseous lesions of the jaws: study of 276 cases. J Stomatol Oral Maxillofac Surg 2022;123:364–371.
Titinchi F, Morkel J. Ossifying fibroma: analysis of treatment methods and recurrence patterns. J Oral Maxillofac Surg 2016;74:2409–2419.
Kawaguchi M, Kato H, Miyazaki T, et al. CT and MR imaging characteristics of histological subtypes of head and neck ossifying fibroma. Dentomaxillofac Radiol 2018;47:20180085.
Liu Y, Wang H, You M, et al. Ossifying fibromas of the jaw bone: 20 cases. Dentomaxillofac Radiol 2010;39:57–63.
Ooi EH, Glicksman JT, Vescan AD, et al. An alternative management approach to paranasal sinus fibro-osseous lesions. Int Forum Allergy Rhinol 2011;1:55–63.
Mastaglia S. Regression of an ossifying fibroma of the tibia after a fracture involving the lesion. Possible role of the periostina. Clin Cases Miner Bone Metab 2015;12:262–264.
Yu Y, Cui C, Guan SY, et al. Function of orofacial stem cells in tooth eruption: an evolving perspective. Chin J Dent Res 2021;24:143–152.

Date Created: 20230605 Date Completed: 20230831 Latest Revision: 20230911

20230912

10.1097/SCS.0000000000009466

37271877