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Five-year results of atropine 0.01% efficacy in the myopia control in a European population.
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- Author(s): Moriche-Carretero M;Moriche-Carretero M;Moriche-Carretero M; Revilla-Amores R; Revilla-Amores R; Gutiérrez-Blanco A; Gutiérrez-Blanco A; Moreno-Morillo FJ; Moreno-Morillo FJ; Martinez-Perez C; Martinez-Perez C; Sánchez-Tena MÁ; Sánchez-Tena MÁ; Sánchez-Tena MÁ; Alvarez-Peregrina C; Alvarez-Peregrina C
- Source:
The British journal of ophthalmology [Br J Ophthalmol] 2024 May 21; Vol. 108 (5), pp. 715-719. Date of Electronic Publication: 2024 May 21.- Publication Type:
Journal Article; Randomized Controlled Trial- Language:
English - Source:
- Additional Information
- Source: Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 0421041 Publication Model: Electronic Cited Medium: Internet ISSN: 1468-2079 (Electronic) Linking ISSN: 00071161 NLM ISO Abbreviation: Br J Ophthalmol Subsets: MEDLINE
- Publication Information: Publication: Jan. 1992- : London : BMJ Pub. Group
Original Publication: 1917-Dec. 1991: London : British Medical Association - Subject Terms: Atropine*/administration & dosage ; Atropine*/therapeutic use ; Mydriatics*/therapeutic use ; Mydriatics*/administration & dosage ; Refraction, Ocular*/physiology ; Ophthalmic Solutions* ; Myopia*/drug therapy ; Myopia*/physiopathology ; Disease Progression* ; Axial Length, Eye*; Humans ; Male ; Female ; Prospective Studies ; Child ; Treatment Outcome ; Follow-Up Studies ; Adolescent ; Europe
- Abstract: Aims: To evaluate the efficacy and safety of 0.01% atropine eye-drops in controlling myopia progression over 5 years.
Methods: Experimental, analytical, prospective, randomised and longitudinal study, in 361 right eyes from 361 children randomised into the control group (177 eyes without treatment) and treatment group (184 eyes with 0.01% atropine eye-drops). Children assigned to the treatment group used 0.01% atropine once a day every night and the control group's children did not use any treatment or placebo. All the subjects completed an eye examination every 6 months for the 5 years of follow-up. The examination included subjective and objective refraction with cycloplegia, axial length (AL), keratometry and anterior chamber depth (ACD) to evaluate the efficacy of the treatment. It also included the anterior and posterior pole examination to evaluate the safety of the treatment.
Results: The SE increased -0.63±0.42D in children after 5 years of treatment with 0.01% atropine, while in the control group the increase was -0.92±0.56D. AL increased 0.26±0.28 mm in the treatment group compared with 0.49±0.34 mm in the control group. Atropine 0.01% showed an efficacy of 31.5% and 46.9% in the control of the SE and AL increase, respectively. ACD and keratometry did not have significant changes between groups.
Conclusions: Atropine 0.01% is effective in slowing myopia progression in a European population. There were no side effects after 5 years of 0.01% atropine.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.) - Contributed Indexing: Keywords: Child health (paediatrics); Epidemiology
- Publication Date: Date Created: 20230602 Date Completed: 20240521 Latest Revision: 20240717
- Publication Date: 20240718
- Accession Number: 10.1136/bjo-2022-322808
- Accession Number: 37268328
- Source:
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