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Tumor-Induced Osteomalacia- Like Syndrome with Rickets and Infantile Hepatic Hemangioendothelioma.
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- Additional Information
- Source:
Publisher: Dr. K. C. Chaudhuri Foundation, co-published by Springer India Country of Publication: India NLM ID: 0417442 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0973-7693 (Electronic) Linking ISSN: 00195456 NLM ISO Abbreviation: Indian J Pediatr Subsets: MEDLINE
- Publication Information:
Publication: [Mumbai] : Dr. K. C. Chaudhuri Foundation, co-published by Springer India
Original Publication: New Delhi : All India Institute Of Medical Sciences
- Subject Terms:
- Abstract:
Tumor-induced osteomalacia (TIO), a rare paraneoplastic syndrome is seen in association with the overproduction of fibroblast growth factor-23 (FGF-23) by certain mesenchymal tumors in adults. In children, these phosphaturic mesenchymal tumors produce features of rickets similar to TIO. This condition is characterized by elevated blood levels of FGF-23, low phosphate, low or normal active vitamin D, and high alkaline phosphatase. Though the removal of the tumor is curative; in cases where surgical resection is not possible, medical treatment is successful with phosphate and active vitamin D in the improvement of symptoms. The case of a child with features of rickets is presented here to illustrate the importance of identifying this rare condition and instituting appropriate intervention.
(© 2023. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation.)
- References:
Florenzano P, Gafni RI, Collins MT. Tumor-induced osteomalacia. Bone Rep. 2017;7:90–7. (PMID: 10.1016/j.bonr.2017.09.002290219955633085)
Beygi S, Denio A, Sharma TS. The foot that broke both hips: A case report and literature review of tumor-induced osteomalacia. Case Rep Rheumatol. 2017;2017:Article ID 3191673.
White KE, Evans WE, O’Riordan JLH, et al. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet. 2000;26:345–8. (PMID: 10.1038/81664)
Kim EH, Koh KN, Park M, Kim BE, Im HJ, Seo JJ. Clinical features of infantile hepatic hemangioendothelioma. Korean J Pediatr. 2011;54:260–6. (PMID: 10.3345/kjp.2011.54.6.260219495213174362)
Kim DH, Sung DH, Min YK. Hypophosphatemic osteomalacia induced by low-dose adefovir therapy: Focus on manifestations in the skeletal system and literature review. J Bone Miner Metab. 2013;31:240–6. (PMID: 10.1007/s00774-012-0384-y22976054)
- Contributed Indexing:
Keywords: Child; Fibroblast growth factor-23; Hypophosphatemia; Rickets; Tumor-induced osteomalacia
- Accession Number:
7Q7P4S7RRE (Fibroblast Growth Factor-23)
0 (FGF23 protein, human)
62031-54-3 (Fibroblast Growth Factors)
- Subject Terms:
Oncogenic osteomalacia
- Publication Date:
Date Created: 20230529 Date Completed: 20240715 Latest Revision: 20240911
- Publication Date:
20240912
- Accession Number:
10.1007/s12098-023-04612-x
- Accession Number:
37248381
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