Tumor-Induced Osteomalacia- Like Syndrome with Rickets and Infantile Hepatic Hemangioendothelioma.

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  • Additional Information
    • Source:
      Publisher: Dr. K. C. Chaudhuri Foundation, co-published by Springer India Country of Publication: India NLM ID: 0417442 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0973-7693 (Electronic) Linking ISSN: 00195456 NLM ISO Abbreviation: Indian J Pediatr Subsets: MEDLINE
    • Publication Information:
      Publication: [Mumbai] : Dr. K. C. Chaudhuri Foundation, co-published by Springer India
      Original Publication: New Delhi : All India Institute Of Medical Sciences
    • Subject Terms:
      Osteomalacia*/etiology ; Fibroblast Growth Factor-23* ; Paraneoplastic Syndromes*/etiology ; Rickets*/complications ; Rickets*/diagnosis ; Rickets*/etiology ; Liver Neoplasms*/complications ; Hemangioendothelioma*/complications; Humans ; Fibroblast Growth Factors/blood ; Infant ; Male ; Female ; Neoplasms, Connective Tissue/etiology
    • Abstract:
      Tumor-induced osteomalacia (TIO), a rare paraneoplastic syndrome is seen in association with the overproduction of fibroblast growth factor-23 (FGF-23) by certain mesenchymal tumors in adults. In children, these phosphaturic mesenchymal tumors produce features of rickets similar to TIO. This condition is characterized by elevated blood levels of FGF-23, low phosphate, low or normal active vitamin D, and high alkaline phosphatase. Though the removal of the tumor is curative; in cases where surgical resection is not possible, medical treatment is successful with phosphate and active vitamin D in the improvement of symptoms. The case of a child with features of rickets is presented here to illustrate the importance of identifying this rare condition and instituting appropriate intervention.
      (© 2023. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation.)
    • References:
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      Beygi S, Denio A, Sharma TS. The foot that broke both hips: A case report and literature review of tumor-induced osteomalacia. Case Rep Rheumatol. 2017;2017:Article ID 3191673.
      White KE, Evans WE, O’Riordan JLH, et al. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet. 2000;26:345–8. (PMID: 10.1038/81664)
      Kim EH, Koh KN, Park M, Kim BE, Im HJ, Seo JJ. Clinical features of infantile hepatic hemangioendothelioma. Korean J Pediatr. 2011;54:260–6. (PMID: 10.3345/kjp.2011.54.6.260219495213174362)
      Kim DH, Sung DH, Min YK. Hypophosphatemic osteomalacia induced by low-dose adefovir therapy: Focus on manifestations in the skeletal system and literature review. J Bone Miner Metab. 2013;31:240–6. (PMID: 10.1007/s00774-012-0384-y22976054)
    • Contributed Indexing:
      Keywords: Child; Fibroblast growth factor-23; Hypophosphatemia; Rickets; Tumor-induced osteomalacia
    • Accession Number:
      7Q7P4S7RRE (Fibroblast Growth Factor-23)
      0 (FGF23 protein, human)
      62031-54-3 (Fibroblast Growth Factors)
    • Subject Terms:
      Oncogenic osteomalacia
    • Publication Date:
      Date Created: 20230529 Date Completed: 20240715 Latest Revision: 20240911
    • Publication Date:
      20240912
    • Accession Number:
      10.1007/s12098-023-04612-x
    • Accession Number:
      37248381