Two new lignan glycosides from Acanthus ilicifolius L. with their NO inhibition and cytotoxic activity.

Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE

Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003-

Glycosides*/pharmacology ; Glycosides*/chemistry ; Glycosides*/isolation & purification ; Lignans*/pharmacology ; Lignans*/chemistry ; Lignans*/isolation & purification ; Nitric Oxide* ; Acanthaceae*/chemistry; Mice ; Humans ; Animals ; RAW 264.7 Cells ; Molecular Structure ; Hep G2 Cells ; Inhibitory Concentration 50 ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/chemistry ; Plant Components, Aerial/chemistry ; Plant Extracts/chemistry ; Plant Extracts/pharmacology

A phytochemical investigation of the methanolic extract of aerial parts of the Acanthus ilicifolius led to the isolation of two new lignan glycosides, acaniliciosides A and B ( 1 and 2 ), together with ten known compounds ( 3 - 12 ). The structures of isolated compounds were elucidated based on HR-ESI-MS, 1D and 2D NMR spectroscopic data. The absolute configurations of two new compounds were established by CD spectra. With the exception of compound 12 , other compounds inhibited NO production in LPS activated RAW264.7 cells with IC 50 values of 2.14-28.18 µM, as potent as that of the positive control of N ^G -monomethyl-L-arginine acetate (L-NMMA, IC 50 of 32.50 µM). In addition, compounds 5 - 8 showed cytotoxic effects against SK-LU-1 and HepG2 cell lines with the IC 50 values ranging from 16.48 to 76.40 μM compared to the positive control (ellipticine) with the IC 50 values ranging from 1.23 to 1.46 μM.

Keywords: Acanthaceae; Acanthus ilicifolius; NO inhibition; acanilicioside A; acanilicioside B;; cytotoxicity

0 (Glycosides)
0 (Lignans)
31C4KY9ESH (Nitric Oxide)
0 (Antineoplastic Agents, Phytogenic)
0 (Plant Extracts)

Date Created: 20230526 Date Completed: 20240912 Latest Revision: 20240912

20240912

10.1080/14786419.2023.2218009

37234021