The ecology of viruses in urban rodents with a focus on SARS-CoV-2.

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  • Additional Information
    • Source:
      Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE
    • Publication Information:
      Publication: 2019- : [Philadelphia, PA] : Taylor & Francis
      Original Publication: New York : NPG, 2012-2018.
    • Subject Terms:
      COVID-19* ; Viruses*; Humans ; Animals ; Rats ; Mice ; SARS-CoV-2 ; Rodentia ; Pandemics ; Antibodies, Viral
    • Abstract:
      Wild animals are naturally infected with a range of viruses, some of which may be zoonotic. During the human COVID pandemic there was also the possibility of rodents acquiring SARS-CoV-2 from people, so-called reverse zoonoses. To investigate this, we sampled rats ( Rattus norvegicus ) and mice ( Apodemus sylvaticus ) from urban environments in 2020 during the human COVID-19 pandemic. We metagenomically sequenced lung and gut tissue and faeces for viruses, PCR screened for SARS-CoV-2, and serologically surveyed for anti-SARS-CoV-2 Spike antibodies. We describe the range of viruses that we found in these two rodent species. We found no molecular evidence of SARS-CoV-2 infection, though in rats we found lung antibody responses and evidence of neutralization ability that are consistent with rats being exposed to SARS-CoV-2 and/or exposed to other viruses that result in cross-reactive antibodies.
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    • Contributed Indexing:
      Keywords: COVID; SARS-CoV-2; Urban; rodents; virome; virus; zoonosis
    • Accession Number:
      0 (Antibodies, Viral)
    • Publication Date:
      Date Created: 20230523 Date Completed: 20230613 Latest Revision: 20230616
    • Publication Date:
      20230616
    • Accession Number:
      PMC10262798
    • Accession Number:
      10.1080/22221751.2023.2217940
    • Accession Number:
      37219409