The Role of Non-coding RNAs in Alzheimer's Disease: Pathogenesis, Novel Biomarkers, and Potential Therapeutic Targets.

Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101269155 Publication Model: Print Cited Medium: Internet ISSN: 1996-3181 (Electronic) Linking ISSN: 18715273 NLM ISO Abbreviation: CNS Neurol Disord Drug Targets Subsets: MEDLINE

Original Publication: Saif Zone, Sharjah, U.A.E.; San Francisco, CA : Bentham Science Publishers, c2006-

Alzheimer Disease*/genetics ; Alzheimer Disease*/metabolism ; Biomarkers*/metabolism ; RNA, Long Noncoding*/genetics ; RNA, Long Noncoding*/metabolism; Humans ; Animals

Long non-coding RNAs (IncRNAs) are regulatory RNA transcripts that have recently been associated with the onset of many neurodegenerative illnesses, including Alzheimer's disease (AD). Several IncRNAs have been found to be associated with AD pathophysiology, each with a distinct mechanism. In this review, we focused on the role of IncRNAs in the pathogenesis of AD and their potential as novel biomarkers and therapeutic targets. Searching for relevant articles was done using the PubMed and Cochrane library databases. Studies had to be published in full text in English in order to be considered. Some IncRNAs were found to be upregulated, while others were downregulated. Dysregulation of IncRNAs expression may contribute to AD pathogenesis. Their effects manifest as the synthesis of beta-amyloid (Aβ) plaques increases, thereby altering neuronal plasticity, inducing inflammation, and promoting apoptosis. Despite the need for more investigations, IncRNAs could potentially increase the sensitivity of early detection of AD. Until now, there has been no effective treatment for AD. Hence, InRNAs are promising molecules and may serve as potential therapeutic targets. Although several dysregulated AD-associated lncRNAs have been discovered, the functional characterization of most lncRNAs is still lacking.
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Keywords: AD pathophysiology.; Alzheimer's disease; Beta-amyloid; biomarkers; lncRNA; pathogenesis

0 (Biomarkers)
0 (RNA, Long Noncoding)

Date Created: 20230522 Date Completed: 20240606 Latest Revision: 20240606

20240606

10.2174/1871527322666230519113201

37211844