Delayed post gadolinium MRI descriptors for Meniere's disease: a systematic review and meta-analysis.

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  • Additional Information
    • Source:
      Publisher: Springer International Country of Publication: Germany NLM ID: 9114774 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1084 (Electronic) Linking ISSN: 09387994 NLM ISO Abbreviation: Eur Radiol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Berlin : Springer International, c1991-
    • Subject Terms:
      Meniere Disease*/diagnostic imaging ; Endolymphatic Hydrops*/diagnosis ; Ear, Inner*/diagnostic imaging; Humans ; Adult ; Middle Aged ; Aged ; Gadolinium/pharmacology ; Magnetic Resonance Imaging/methods
    • Abstract:
      Objectives: Delayed post-gadolinium magnetic resonance imaging (MRI) detects changes of endolymphatic hydrops (EH) within the inner ear in Meniere's disease (MD). A systematic review with meta-analysis was conducted to summarise the diagnostic performance of MRI descriptors across the range of MD clinical classifications.
      Materials and Methods: Case-controlled studies documenting the diagnostic performance of MRI descriptors in distinguishing MD ears from asymptomatic ears or ears with other audio-vestibular conditions were identified (MEDLINE, EMBASE, Web of Science, Scopus databases: updated 17/2/2022). Methodological quality was evaluated with Quality Assessment of Diagnostic Accuracy Studies version 2. Results were pooled using a bivariate random-effects model for evaluation of sensitivity, specificity and diagnostic odds ratio (DOR). Meta-regression evaluated sources of heterogeneity, and subgroup analysis for individual clinical classifications was performed.
      Results: The meta-analysis included 66 unique studies and 3073 ears with MD (mean age 40.2-67.2 years), evaluating 11 MRI descriptors. The combination of increased perilymphatic enhancement (PLE) and EH (3 studies, 122 MD ears) achieved the highest sensitivity (87% (95% CI: 79.92%)) whilst maintaining high specificity (91% (95% CI: 85.95%)). The diagnostic performance of "high grade cochlear EH" and "any EH" descriptors did not significantly differ between monosymptomatic cochlear MD and the latest reference standard for definite MD (p = 0.3; p = 0.09). Potential sources of bias were case-controlled design, unblinded observers and variable reference standard, whilst differing MRI techniques introduced heterogeneity.
      Conclusions: The combination of increased PLE and EH optimised sensitivity and specificity for MD, whilst some MRI descriptors also performed well in diagnosing monosymptomatic cochlear MD.
      Key Points: • A meta-analysis of delayed post-gadolinium magnetic resonance imaging (MRI) for the diagnosis of Meniere's disease is reported for the first time and comprised 66 studies (3073 ears). • Increased enhancement of the perilymphatic space of the inner ear is shown to be a key MRI feature for the diagnosis of Meniere's disease. • MRI diagnosis of Meniere's disease can be usefully applied across a range of clinical classifications including patients with cochlear symptoms alone.
      (© 2023. Crown.)
    • References:
      J Clin Epidemiol. 2016 Jul;75:40-6. (PMID: 27005575)
      Acta Otorhinolaryngol Ital. 2018 Aug;38(4):369-376. (PMID: 30197428)
      Laryngoscope. 2016 Apr;126(4):974-9. (PMID: 26333096)
      Ann Otol Rhinol Laryngol. 2018 Nov;127(11):777-782. (PMID: 30156867)
      Audiol Neurootol. 2012;17(2):126-32. (PMID: 21985844)
      Neuroradiology. 2022 May;64(5):1011-1020. (PMID: 35149883)
      J Clin Epidemiol. 2005 Sep;58(9):882-93. (PMID: 16085191)
      AJNR Am J Neuroradiol. 2018 Nov;39(11):2114-2119. (PMID: 30337432)
      Acta Otolaryngol. 2011 May;131(5):474-9. (PMID: 21198346)
      J Neuroradiol. 2021 Nov;48(6):446-452. (PMID: 31034895)
      Acta Otolaryngol. 2017 Jan;137(1):23-28. (PMID: 27564645)
      Acta Otolaryngol. 2011 Jun;131(6):602-9. (PMID: 21344957)
      Acta Otolaryngol. 2020 Oct;140(10):818-822. (PMID: 32646259)
      Magn Reson Med Sci. 2012;11(1):43-51. (PMID: 22450386)
      BMJ Open. 2013 Feb 14;3(2):. (PMID: 23418296)
      Laryngoscope. 2007 Mar;117(3):415-20. (PMID: 17279053)
      Auris Nasus Larynx. 2019 Apr;46(2):210-217. (PMID: 30205916)
      Acta Otolaryngol. 2020 Sep;140(9):723-727. (PMID: 32700983)
      PLoS Med. 2009 Jul 21;6(7):e1000097. (PMID: 19621072)
      Ear Hear. 2019 Jan/Feb;40(1):168-176. (PMID: 29698363)
      Auris Nasus Larynx. 2021 Feb;48(1):15-22. (PMID: 33131962)
      Acta Radiol. 2022 Jun;63(6):810-813. (PMID: 34000823)
      BMC Med Inform Decis Mak. 2007 Jun 15;7:16. (PMID: 17573961)
      Front Surg. 2021 Jul 20;8:667248. (PMID: 34355012)
      Sci Rep. 2021 Mar 30;11(1):7212. (PMID: 33785791)
      Radiologia. 2017 Mar - Apr;59(2):159-165. (PMID: 28017456)
      J Laryngol Otol. 2023 Mar;137(3):239-245. (PMID: 35674257)
      Neuroradiology. 2019 Apr;61(4):421-429. (PMID: 30719545)
      Laryngoscope. 2013 Feb;123(2):503-6. (PMID: 22865507)
      J Vestib Res. 2021;31(4):261-268. (PMID: 33646188)
      AJNR Am J Neuroradiol. 2020 Apr;41(4):706-711. (PMID: 32193190)
      J Neurol. 2018 Oct;265(Suppl 1):51-53. (PMID: 29696496)
      Front Neurol. 2021 Mar 11;12:594481. (PMID: 33776877)
      Med Sci Monit. 2015 Mar 06;21:701-7. (PMID: 25742875)
      Front Surg. 2022 Jan 12;8:673323. (PMID: 35096954)
      AJNR Am J Neuroradiol. 2014 Jul;35(7):1387-92. (PMID: 24524921)
      Acta Otolaryngol. 2011 Jun;131(6):596-601. (PMID: 21351819)
      Ann Intern Med. 2011 Oct 18;155(8):529-36. (PMID: 22007046)
      Front Surg. 2021 Jun 21;8:682245. (PMID: 34235173)
      Auris Nasus Larynx. 2022 Feb;49(1):34-45. (PMID: 33865653)
      Acta Otolaryngol. 2021 Aug;141(8):736-741. (PMID: 34346271)
      AJNR Am J Neuroradiol. 2012 Apr;33(4):773-8. (PMID: 22173762)
      J Vestib Res. 2019;29(2-3):121-129. (PMID: 31356219)
      HNO. 2018 Jun;66(6):455-463. (PMID: 29500497)
      Otolaryngol Head Neck Surg. 2005 Nov;133(5):762-8. (PMID: 16274806)
      Front Neurol. 2021 May 20;12:662264. (PMID: 34093410)
      Otol Neurotol. 2011 Apr;32(3):472-7. (PMID: 21307806)
      Eur Arch Otorhinolaryngol. 2017 Dec;274(12):4103-4111. (PMID: 28948373)
      Braz J Otorhinolaryngol. 2020 Mar - Apr;86(2):165-173. (PMID: 30600169)
      Br J Radiol. 2021 Mar 01;94(1119):20200996. (PMID: 33449817)
      Otol Neurotol. 2011 Jul;32(5):887-92. (PMID: 21512426)
      J Vestib Res. 2015;25(1):1-7. (PMID: 25882471)
      Diagn Interv Imaging. 2018 May;99(5):271-277. (PMID: 29398574)
      Otol Neurotol. 2014 Dec;35(10):e337-42. (PMID: 25251300)
      AJNR Am J Neuroradiol. 2020 Mar;41(3):529-534. (PMID: 32029469)
      Acta Otolaryngol. 2012 Mar;132(3):241-6. (PMID: 22201230)
      Eur J Radiol. 2012 Feb;81(2):331-8. (PMID: 21330087)
      J Neuroradiol. 2017 Sep;44(5):339-343. (PMID: 28669534)
      J Neuroradiol. 2020 Mar;47(2):174-179. (PMID: 30423380)
      J Laryngol Otol. 2020 Apr;134(4):302-310. (PMID: 32241307)
      Otolaryngol Head Neck Surg. 1985 Oct;93(5):579-81. (PMID: 2932668)
      Eur Radiol. 2020 Nov;30(11):6331-6338. (PMID: 32537729)
      Otol Neurotol. 2021 Dec 1;42(10):e1532-e1536. (PMID: 34766949)
      PLoS One. 2017 Nov 30;12(11):e0188301. (PMID: 29190293)
      Eur Radiol. 2017 Aug;27(8):3138-3146. (PMID: 27999985)
      J Neurol. 2014 Nov;261(11):2079-84. (PMID: 25099513)
      Front Surg. 2021 Aug 23;8:700271. (PMID: 34497826)
      Auris Nasus Larynx. 2018 Feb;45(1):33-38. (PMID: 28256285)
      Front Neurol. 2021 Sep 13;12:710422. (PMID: 34589046)
      Trans Am Acad Ophthalmol Otolaryngol. 1972 Nov-Dec;76(6):1462-4. (PMID: 4666434)
      JAMA. 1999 Sep 15;282(11):1061-6. (PMID: 10493205)
      Laryngoscope. 2017 Oct;127(10):2382-2388. (PMID: 28220492)
      Magn Reson Med Sci. 2013;12(2):147-51. (PMID: 23666157)
      Proc R Soc Med. 1938 Sep;31(11):1317-36. (PMID: 19991672)
      Front Surg. 2020 Dec 18;7:601692. (PMID: 33392247)
      Otol Neurotol. 2013 Sep;34(7):1241-6. (PMID: 23921924)
      Laryngoscope. 2020 Jul;130(7):E444-E452. (PMID: 31742710)
      Acta Otolaryngol. 2021 Oct;141(10):899-906. (PMID: 34520311)
      Eur Arch Otorhinolaryngol. 2022 Feb;279(2):713-721. (PMID: 33651151)
      Magn Reson Med Sci. 2012;11(2):145-50. (PMID: 22790302)
      AJNR Am J Neuroradiol. 2016 Oct;37(10):1903-1908. (PMID: 27256854)
      Diagn Interv Imaging. 2017 Oct;98(10):699-706. (PMID: 28645678)
      Eur Radiol. 2018 Jul;28(7):2916-2922. (PMID: 29564597)
      Otol Neurotol. 2010 Apr;31(3):455-9. (PMID: 20104195)
      Acta Otolaryngol Suppl. 2009 Feb;(560):5-8. (PMID: 19221900)
      Laryngoscope. 2008 Mar;118(3):501-5. (PMID: 18091332)
      Front Neurol. 2017 Aug 15;8:415. (PMID: 28861037)
      Front Surg. 2021 May 31;8:673847. (PMID: 34136529)
      Front Neurol. 2021 Apr 22;12:647296. (PMID: 33967941)
      J Formos Med Assoc. 2022 Jul;121(7):1325-1333. (PMID: 34686411)
      Magn Reson Med Sci. 2010;9(1):23-9. (PMID: 20339263)
      Acta Otolaryngol. 2016 Sep;136(9):879-82. (PMID: 27080254)
      Acta Otolaryngol. 2003 Apr;123(3):388-95. (PMID: 12737296)
      Acta Otolaryngol. 2020 Nov;140(11):883-888. (PMID: 32692635)
      Eur Arch Otorhinolaryngol. 2019 Jan;276(1):27-40. (PMID: 30306317)
      Otol Neurotol. 2017 Sep;38(8):1076-1080. (PMID: 28708796)
      Acta Otolaryngol. 2010 Aug;130(8):917-23. (PMID: 20105111)
      J Laryngol Otol. 2012 May;126(5):454-9. (PMID: 22314202)
      Eur Arch Otorhinolaryngol. 2021 Sep;278(9):3267-3273. (PMID: 33037440)
      Otolaryngol Head Neck Surg. 1995 Sep;113(3):181-5. (PMID: 7675476)
    • Grant Information:
      WT 203148/Z/16/Z Centre For Medical Engineering, King's College London; A27066 Cancer Research UK National Cancer Imaging Translational Accelerator
    • Contributed Indexing:
      Keywords: Ear, inner; Endolymphatic hydrops; Gadolinium; Magnetic resonance imaging; Odds ratio
    • Accession Number:
      AU0V1LM3JT (Gadolinium)
    • Publication Date:
      Date Created: 20230512 Date Completed: 20230921 Latest Revision: 20240925
    • Publication Date:
      20240925
    • Accession Number:
      PMC10511628
    • Accession Number:
      10.1007/s00330-023-09651-8
    • Accession Number:
      37171493