Influence of Paleobacteria on the Proliferative Activity of Human Lymphocytes In Vitro.

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    • Source:
      Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE
    • Publication Information:
      Publication: New York : Springer
      Original Publication: New York, Consultants Bureau.
    • Subject Terms:
    • Abstract:
      When testing the proliferative activity of 14 strains of permafrost microorganisms in the reaction of blast transformation of human lymphocytes in vitro, a strain (Alcaligenes sp.) with mitogen properties was isolated (20-fold increase in the rate of lymphocyte proliferation in comparison with the control). Four strains activated lymphocyte proliferation by 3-9 times in comparison with the control. Three strains produced substances with cytostatic properties and reduced proliferation activity by 33-43% and one strain (Bacillus sp.) almost completely suppressed phytohemagglutinin-induced lymphocyte proliferation. These data indicate that strains with a unique immunobiological potential are concentrated in the population of permafrost microorganisms that have undergone rigorous evolutionary selection.
      (© 2023. Springer Science+Business Media, LLC, part of Springer Nature.)
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    • Contributed Indexing:
      Keywords: cytostatics; lymphocyte blast transformation reaction; mitogens; paleobacteria antigens; permafrost microorganisms
    • Accession Number:
      0 (Mitogens)
      0 (Phytohemagglutinins)
    • Publication Date:
      Date Created: 20230510 Date Completed: 20230522 Latest Revision: 20230522
    • Publication Date:
      20240829
    • Accession Number:
      10.1007/s10517-023-05787-1
    • Accession Number:
      37162627