Salivary and serum periostin in kidney transplant recipients.

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  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
      Transplant Recipients* ; Kidney Failure, Chronic*/surgery ; Kidney Transplantation* ; Cell Adhesion Molecules*/blood; Humans ; Saliva/chemistry ; Biomarkers/analysis ; Cross-Sectional Studies ; Male ; Female ; Adult ; Middle Aged
    • Abstract:
      Introduction: End-stage renal disease (ESRD) treatment includes dialysis and kidney transplantation. Transplant rejection is a major barrier to transplant success. One of the markers mentioned in previous studies on renal function in patients with renal failure for various reasons is periostin (POSTN). The expression of POSTN correlates with interstitial fibrosis and reduced renal function. One of the limitations in this regard is the effect of oral lesions on the POSTN level. This study was conducted aimed to measure the relationship between salivary and serum POSTN and renal function in patients with a history of a kidney transplant, taking into account all the conditions affecting POSTN.
      Methods: In this study, serum and saliva samples were taken from 23 transplant patients with normal function (NF) and 29 transplant patients with graft failure (GF). At least one year had passed since the transplant. Before sampling, a complete oral examination was performed. Salivary and serum POSTN was examined by ELISA. The results were analyzed by SPSS software.
      Results: The POSTN level in the serum of the NF group (191.00 ± 33.42) was higher than GF patients (178.71 ± 25.68), but the difference was not significant (P = 0.30). Salivary POSTN in NF patients (2.76 ± 0.35) was significantly higher than GF patients (2.44 ± 0.60) (P = 0.01).
      Conclusions: The superiority of saliva as a diagnostic fluid includes ease of collection and storage, and non-invasiveness, all of which can lead to the replacement of blood with this bio-fluid. The significant results of salivary POSTN may be due to the lack of serum disturbing factors. Saliva is an ultra-filtered fluid from serum and therefore there are fewer proteins and polysaccharides attached to biomarkers in saliva and the accuracy of measuring these biomarkers in the saliva is more valuable than serum.
      Competing Interests: The authors have declared that no competing interests exist.
      (Copyright: © 2023 Aghamir et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
    • References:
      Eur J Dent. 2020 Jul;14(3):462-466. (PMID: 32688410)
      Front Med (Lausanne). 2019 Jan 08;5:358. (PMID: 30671435)
      Adv Exp Med Biol. 2019;1132:99-112. (PMID: 31037629)
      Int J Oral Sci. 2016 Sep 29;8(3):133-7. (PMID: 27585820)
      Curr Opin Organ Transplant. 2019 Feb;24(1):103-110. (PMID: 30540576)
      J Periodontal Res. 2015 Dec;50(6):707-13. (PMID: 25529858)
      J Dent Res. 2015 Apr;94(4):540-6. (PMID: 25680368)
      Cancer Biother Radiopharm. 2019 Sep;34(7):444-450. (PMID: 31170012)
      Clin Exp Nephrol. 2019 Aug;23(8):1050-1057. (PMID: 31104272)
      J Asthma Allergy. 2020 Jan 08;13:23-37. (PMID: 32021310)
      J Nephrol. 2019 Feb;32(1):139-150. (PMID: 30628019)
      World J Urol. 2007 Oct;25(5):445-55. (PMID: 17786452)
      Inflammation. 2016 Jun;39(3):986-93. (PMID: 26931107)
      Pediatr Nephrol. 2019 Apr;34(4):599-603. (PMID: 30039433)
      Exp Ther Med. 2018 Jun;15(6):5141-5147. (PMID: 29805541)
      J Indian Soc Periodontol. 2018 Jan-Feb;22(1):25-27. (PMID: 29568168)
      Int J Urol. 2020 Jun;27(6):480-490. (PMID: 32239562)
      Clin Chem Lab Med. 2018 Dec 19;57(2):230-237. (PMID: 30052514)
      Transplant Proc. 2014 Jan-Feb;46(1):135-40. (PMID: 24507039)
      Nephrol Dial Transplant. 2017 Apr 1;32(suppl_2):ii68-ii76. (PMID: 28206633)
      Clin J Am Soc Nephrol. 2010 Jun;5(6):1003-9. (PMID: 20299365)
      J Clin Periodontol. 2018 Jun;45 Suppl 20:S149-S161. (PMID: 29926495)
      Nephrol Dial Transplant. 2007 Sep;22 Suppl 9:ix8-18. (PMID: 17998238)
      Nat Rev Rheumatol. 2018 Jun;14(6):354-362. (PMID: 29760435)
      J Am Soc Nephrol. 2020 Jan;31(1):85-100. (PMID: 31690575)
      Toxins (Basel). 2021 Aug 16;13(8):. (PMID: 34437442)
      J Diabetes Res. 2018 Feb 8;2018:2852398. (PMID: 29577044)
      Diagnostics (Basel). 2021 Jul 31;11(8):. (PMID: 34441325)
      Curr Opin HIV AIDS. 2010 Nov;5(6):463-6. (PMID: 20978388)
    • Accession Number:
      0 (POSTN protein, human)
      0 (Cell Adhesion Molecules)
      0 (Biomarkers)
    • Publication Date:
      Date Created: 20230502 Date Completed: 20230817 Latest Revision: 20230817
    • Publication Date:
      20230818
    • Accession Number:
      PMC10153693
    • Accession Number:
      10.1371/journal.pone.0285256
    • Accession Number:
      37130146