Inhibitory mechanisms of promising antimicrobials from plant byproducts: A review.

Publisher: Institute of Food Technologists Country of Publication: United States NLM ID: 101305205 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1541-4337 (Electronic) Linking ISSN: 15414337 NLM ISO Abbreviation: Compr Rev Food Sci Food Saf Subsets: MEDLINE

Original Publication: Chicago, Ill. : Institute of Food Technologists

Plant Extracts*/pharmacology ; Anti-Infective Agents*/pharmacology; Bacteria ; Microbial Sensitivity Tests

Plant byproducts and waste present enormous environmental challenges and an opportunity for valorization and industrial application. Due to consumer demands for natural compounds, the evident paucity of novel antimicrobial agents against foodborne pathogens, and the urgent need to improve the arsenal against infectious diseases and antimicrobial resistance (AMR), plant byproduct compounds have attracted significant research interest. Emerging research highlighted their promising antimicrobial activity, yet the inhibitory mechanisms remain largely unexplored. Therefore, this review summarizes the overall research on the antimicrobial activity and inhibitory mechanisms of plant byproduct compounds. A total of 315 natural antimicrobials from plant byproducts, totaling 1338 minimum inhibitory concentrations (MIC) (in μg/mL) against a broad spectrum of bacteria, were identified, and a particular emphasis was given to compounds with high or good antimicrobial activity (typically <100 μg/mL MIC). Moreover, the antimicrobial mechanisms, particularly against bacterial pathogens, were discussed in-depth, summarizing the latest research on using natural compounds to combat pathogenic microorganisms and AMR. Furthermore, safety concerns, relevant legislation, consumer perspective, and current gaps in the valorization of plant byproducts-derived compounds were comprehensively discussed. This comprehensive review covering up-to-date information on antimicrobial activity and mechanisms represents a powerful tool for screening and selecting the most promising plant byproduct compounds and sources for developing novel antimicrobial agents.
(© 2023 Institute of Food Technologists®.)

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32001799 National Natural Science Foundation of China; 32272474 National Natural Science Foundation of China; LR23C200002 Science Fund for Distinguished Young Scholars of Zhejiang Province, China; LQ20C200014 Natural Science Foundation of Zhejiang Province

Keywords: antimicrobial resistance; bacterial pathogens; inhibitory mechanisms; natural antimicrobial agents; plant byproducts

0 (Plant Extracts)
0 (Anti-Infective Agents)

Date Created: 20230418 Date Completed: 20230717 Latest Revision: 20240515

20240516

10.1111/1541-4337.13152

37070214