Development of Th1-type immune responses requires the type I cytokine receptor TCCR.

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    • Subject Terms:
      CYTOKINES; TH1 cells; IMMUNE response; IMMUNE system
    • Abstract:
      Reports a new member of the type I cytokine receptor family, designated T-cell cytokine receptor (TCCR). TCCR-deficient mice, which were lacking in T-helper cell response, had increased susceptibility to infection, and had low levels of antigen-specific immunoglobin-gamma-2a; How these results demonstrate the existence of a cytokine receptor involved in regulating the adaptive immune response and critical to the generation of the T-helper cell 1 (Th1) response.