Viruses and amyloids - a vicious liaison.

Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101472305 Publication Model: Print Cited Medium: Internet ISSN: 1933-690X (Electronic) Linking ISSN: 19336896 NLM ISO Abbreviation: Prion Subsets: MEDLINE

Publication: 2015- : Philadelphia, PA : Taylor & Francis
Original Publication: Austin, Tex. : Landes Bioscience, 2007-

COVID-19* ; Viruses* ; Virus Diseases*/complications; Humans ; SARS-CoV-2 ; Post-Acute COVID-19 Syndrome ; Amyloid ; Viral Proteins

The crosstalk between viral infections, amyloid formation and neurodegeneration has been discussed with varying intensity since the last century. Several viral proteins are known to be amyloidogenic. Post-acute sequalae (PAS) of viral infections is known for several viruses. SARS-CoV-2 and COVID-19 implicate connections between amyloid formation and severe outcomes in the acute infection, PAS and neurodegenerative diseases. Is the amyloid connection causation or just correlation? In this review we highlight several aspects where amyloids and viruses meet. The evolutionary driving forces that dictate protein amyloid formation propensity are different for viruses compared to prokaryotes and eukaryotes, while posttranslational endoproteolysis appears to be a common mechanism leading up to amyloid formation for both viral and human proteins. Not only do human and viral proteins form amyloid irrespective of each other but there are also several examples of co-operativity between amyloids, viruses and the inter-, and intra-host spread of the respective entity. Abnormal blood clotting in severe and long COVID and as a side effect in some vaccine recipients has been connected to amyloid formation of both the human fibrin and the viral Spike-protein. We conclude that there are many intersects between viruses and amyloids and, consequently, amyloid and virus research need to join forces here. We emphasize the need to accelerate development and implementation in clinical practice of antiviral drugs to preclude PAS and downstream neurological damage. There is also an ample need for retake on suitable antigen targets for the further development of next generation of vaccines against the current and coming pandemics.

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Keywords: Amyloid; PASC; SARS-CoV-2; long COVID; post-acute sequalae COVID-19; virus

0 (Amyloid)
0 (Viral Proteins)

Date Created: 20230331 Date Completed: 20230403 Latest Revision: 20230622

20240628

PMC10072076

10.1080/19336896.2023.2194212

36998202