Maternal androgens and autism spectrum disorder in the MARBLES prospective cohort study.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101300021 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1750-9467 (Print) NLM ISO Abbreviation: Res Autism Spectr Disord Subsets: PubMed not MEDLINE
    • Publication Information:
      Original Publication: Amsterdam : Elsevier
    • Abstract:
      Background: Maternal hormonal risk factors for autism spectrum disorder (ASD) in offspring could intersect genetic and environmental risk factors.
      Objectives: This analysis explored ASD risk in association with maternal testosterone, androstenedione, and dehydroepiandrosterone (DHEA) measured in first, second, and third trimesters of pregnancy.
      Methods: MARBLES is a prospective pregnancy cohort study based at the MIND Institute in Northern California that enrolls mothers who have at least one child previously diagnosed with ASD and are expecting, or planning to have another child. At 36 months the younger sibling is clinically classified as having ASD, or as non-typically developing (Non-TD), or typically developing (TD). Maternal androgens during pregnancy were measured in serum samples from 196 mothers. Multivariable logistic regression models estimated risk of ASD and Non-TD in offspring compared to TD, in relation to the log-transformed maternal androgen concentrations, at each trimester.
      Results: Non-significant associations were observed, and borderline significant associations were only observed in some stratified unadjusted models. Second trimester maternal testosterone was non-significantly associated with ASD in female offspring, although not after adjustment, aRR 1.54 (95% CI 0.71, 3.33), and second trimester maternal DHEA was non-significantly associated with non-TD in male offspring, again not after adjustment, aRR 0.50 (95% CI 0.21, 1.21). Secondary analysis suggested that third trimester androgen concentrations in mothers with male offspring had significant or near significant associations with their child's Social Responsiveness Scale score.
      Conclusion: No significant associations were found between maternal androgen concentrations and risk of ASD or Non-TD in the child.
      Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: RJ Schmidt receives research funding from the Simons Foundation, was a paid consultant for a research study at Drexel University, and has received honoraria from NIH for grant reviews. A-M Iosif has received honoraria for reviewing activities from Elsevier, NIH and Department of Defense. L Granillo and NW Snyder declare no competing financial interests.
    • References:
      Pflugers Arch. 2013 May;465(5):557-71. (PMID: 23588379)
      Mol Psychiatry. 2020 Nov;25(11):2970-2978. (PMID: 31358906)
      J Am Acad Child Adolesc Psychiatry. 2014 Apr;53(4):398-407.e2. (PMID: 24655649)
      J Autism Dev Disord. 2003 Aug;33(4):427-33. (PMID: 12959421)
      J Bioeth Inq. 2012 Mar;9(1):93-103. (PMID: 23180205)
      Front Cell Neurosci. 2015 Jul 08;9:257. (PMID: 26217183)
      J Autism Dev Disord. 2019 Nov;49(11):4572-4583. (PMID: 31410696)
      Steroids. 2016 Dec;116:60-66. (PMID: 27743906)
      J Child Psychol Psychiatry. 2016 Dec;57(12):1455-1462. (PMID: 27460188)
      J Clin Endocrinol Metab. 2018 Jun 1;103(6):2116-2125. (PMID: 29648599)
      J Am Acad Child Adolesc Psychiatry. 2012 May;51(5):477-486.e1. (PMID: 22525954)
      Dialogues Clin Neurosci. 2016 Dec;18(4):361-372. (PMID: 28179808)
      Mol Psychiatry. 2019 Dec;24(12):1787-1797. (PMID: 30867561)
      Am J Epidemiol. 2021 Apr 6;190(4):600-610. (PMID: 33521821)
      J Clin Endocrinol Metab. 2011 Sep;96(9):E1491-5. (PMID: 21752884)
      Mol Psychiatry. 2016 Oct;21(10):1441-8. (PMID: 26643539)
      Pediatr Res. 2018 Aug;84(2):190-198. (PMID: 29538366)
      Neurosci Biobehav Rev. 2008 Oct;32(8):1519-32. (PMID: 18598714)
      Obstet Gynecol. 2011 Nov;118(5):1029-1036. (PMID: 22015870)
      Transl Psychiatry. 2020 Jan 16;10(1):7. (PMID: 32066706)
      J Clin Endocrinol Metab. 1973 Jul;37(1):74-8. (PMID: 4715296)
      Psychoneuroendocrinology. 2022 Feb;136:105623. (PMID: 34896742)
      Scand J Clin Lab Invest. 2003;63(1):23-6. (PMID: 12729066)
      Endocr Rev. 2014 Dec;35(6):961-91. (PMID: 25211453)
      Trends Cogn Sci. 2002 Jun 1;6(6):248-254. (PMID: 12039606)
      Mol Psychiatry. 2015 Mar;20(3):369-76. (PMID: 24888361)
      Curr Opin Neurol. 2013 Apr;26(2):146-53. (PMID: 23406909)
      J Health Soc Behav. 1983 Dec;24(4):385-96. (PMID: 6668417)
      Mol Autism. 2016 Jan 21;7:10. (PMID: 26798446)
      J Autism Dev Disord. 2017 Dec;47(12):3994-4005. (PMID: 28900768)
      J Genet Psychol. 1989 Mar;150(1):101-12. (PMID: 2496195)
      Mol Autism. 2017 Jan 31;8:3. (PMID: 28163867)
      Mol Autism. 2020 Nov 23;11(1):93. (PMID: 33228808)
      J Autism Dev Disord. 2009 May;39(5):693-705. (PMID: 19082876)
      Mol Autism. 2021 Jul 8;12(1):51. (PMID: 34238355)
      Physiol Behav. 2015 Jan;138:13-20. (PMID: 25455866)
      Mol Autism. 2014 Apr 09;5:27. (PMID: 24717046)
      Mol Autism. 2021 Jun 9;12(1):43. (PMID: 34108004)
      Eur J Endocrinol. 2006 Aug;155(2):365-70. (PMID: 16868152)
      J Autism Dev Disord. 2002 Jun;32(3):207-15. (PMID: 12108622)
      Ann Intern Med. 2017 Aug 15;167(4):268-274. (PMID: 28693043)
      Biol Sex Differ. 2015 Feb 26;6:3. (PMID: 25745554)
      Paediatr Perinat Epidemiol. 2016 Sep;30(5):479-87. (PMID: 27239935)
      BMC Med Res Methodol. 2008 Oct 30;8:70. (PMID: 18973665)
      Transl Psychiatry. 2018 Aug 1;8(1):136. (PMID: 30065244)
      J Steroid Biochem Mol Biol. 2016 Jan;155(Pt B):217-23. (PMID: 24816231)
      Annu Rev Public Health. 2007;28:235-58. (PMID: 17367287)
      Paediatr Perinat Epidemiol. 2014 Jan;28(1):58-66. (PMID: 24313668)
      Eur J Contracept Reprod Health Care. 2022 Jun;27(3):253-260. (PMID: 35191798)
      Reprod Toxicol. 2020 Mar;92:14-56. (PMID: 31055053)
      J Autism Dev Disord. 2013 May;43(5):1151-6. (PMID: 23001766)
      Hum Reprod. 2020 Oct 1;35(10):2336-2347. (PMID: 32866965)
      JAMA Psychiatry. 2019 Oct 1;76(10):1035-1043. (PMID: 31314057)
      J Clin Endocrinol Metab. 1974 Apr;38(4):612-7. (PMID: 4856555)
      Br J Psychiatry. 2010 Apr;196(4):274-81. (PMID: 20357302)
      Endocrinology. 2004 Feb;145(2):790-8. (PMID: 14576190)
      Annu Rev Public Health. 2017 Mar 20;38:81-102. (PMID: 28068486)
      J Neurodev Disord. 2012 Oct 30;4(1):25. (PMID: 23110806)
      Autism. 2022 Feb;26(2):373-388. (PMID: 34184558)
      Environ Health Perspect. 2018 Nov;126(11):117004. (PMID: 30465702)
      Reprod Biomed Online. 2013 Jul;27(1):33-63. (PMID: 23669015)
      Biol Sex Differ. 2016 Nov 16;7:58. (PMID: 27891212)
    • Grant Information:
      U54 HD079125 United States HD NICHD NIH HHS; P30 ES023513 United States ES NIEHS NIH HHS; R21 HD087866 United States HD NICHD NIH HHS; P50 HD103526 United States HD NICHD NIH HHS; UL1 TR000002 United States TR NCATS NIH HHS; R24 ES028533 United States ES NIEHS NIH HHS; K22 ES026235 United States ES NIEHS NIH HHS; P50 MH106438 United States MH NIMH NIH HHS; P01 ES011269 United States ES NIEHS NIH HHS; R01 ES028089 United States ES NIEHS NIH HHS; R01 ES020392 United States ES NIEHS NIH HHS; R01 ES025574 United States ES NIEHS NIH HHS; K12 HD051958 United States HD NICHD NIH HHS
    • Contributed Indexing:
      Keywords: Androstenedione; Autism; Pregnancy; Prospective study; Testosterone
    • Publication Date:
      Date Created: 20230320 Latest Revision: 20231102
    • Publication Date:
      20240628
    • Accession Number:
      PMC10022653
    • Accession Number:
      10.1016/j.rasd.2022.102054
    • Accession Number:
      36938498