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Haptoglobin genotype and its relation to asymptomatic cerebral small-vessel disease in type 1 diabetes.
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- Author(s): Eriksson MI;Eriksson MI;Eriksson MI;Eriksson MI; Syreeni A; Syreeni A; Syreeni A; Syreeni A; Sandholm N; Sandholm N; Sandholm N; Sandholm N; Dahlström EH; Dahlström EH; Dahlström EH; Dahlström EH; Gordin D; Gordin D; Gordin D; Gordin D; Gordin D; Tatlisumak T; Tatlisumak T; Tatlisumak T; Tatlisumak T; Putaala J; Putaala J; Groop PH; Groop PH; Groop PH; Groop PH; Groop PH; Martola J; Martola J; Martola J; Thorn LM; Thorn LM; Thorn LM; Thorn LM; Thorn LM
- Source:
Acta diabetologica [Acta Diabetol] 2023 Jun; Vol. 60 (6), pp. 749-756. Date of Electronic Publication: 2023 Mar 01.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Corporate Authors:
- Source: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5233 (Electronic) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE
- Publication Information: Publication: Berlin : Springer Verlag
Original Publication: Berlin : Springer International, c1991- - Subject Terms: Stroke, Lacunar* ; Diabetes Mellitus, Type 1*/complications ; Diabetes Mellitus, Type 1*/epidemiology ; Diabetes Mellitus, Type 1*/genetics ; Cerebral Small Vessel Diseases*/epidemiology ; Cerebral Small Vessel Diseases*/genetics; Adult ; Humans ; Female ; Middle Aged ; Haptoglobins/genetics ; Cross-Sectional Studies ; Genotype ; Cerebral Hemorrhage/etiology ; Cerebral Hemorrhage/genetics ; Chromosomal Proteins, Non-Histone/genetics
- Abstract: Aim: Cerebral small-vessel disease (SVD) is prevalent in type 1 diabetes and has been associated with the haptoglobin variant allele Hp1. Contrarily, the Hp2-allele has been linked to cardiovascular disease and the role of haptoglobin-genotype in asymptomatic SVD is unknown. We, therefore, aimed to evaluate the alleles' association with SVD.
Methods: This cross-sectional study included 179 neurologically asymptomatic adults with type 1 diabetes (women 53%, mean age 39 ± 7 years, diabetes duration 23 ± 10 years, HbA1c 8.1 ± 3.2% [65 ± 12 mmol/mol]). Examinations included genotyping (genotypes Hp1-1, Hp2-1, Hp2-2) by polymerase chain reaction, clinical investigation, and magnetic resonance brain images assessed for SVD manifestations (white matter hyperintensities, cerebral microbleeds, and lacunar infarcts).
Results: SVD prevalence was 34.6%. Haptoglobin genotype frequencies were 15.6% (Hp1-1), 43.6% (Hp1-2), and 40.8% (Hp2-2). Only diastolic blood pressure differed between the genotypes Hp1-1, Hp1-2, and Hp2-2 (81 [74-83], 75 [70-80], and 75 [72-81] mmHg, p = 0.019). Haptoglobin genotype frequencies by presence versus absence of SVD were 16.1%; 46.8%; 37.1% versus 15.4%; 41.9%; 42.7% (p = 0.758). Minor allele frequencies were 39.5% versus 36.3% (p = 0.553). Hp1 homozygotes and Hp2 carriers displayed equal proportions of SVD (35.7% vs 34.4%, p > 0.999) and SVD manifestations (white matter hyperintensities 14.3% vs 17.9%, p = 0.790; microbleeds 25.0% vs 21.9%, p = 0.904; lacunar infarcts 0% vs 3.6%, p > 0.999). Hp1-1 was not associated with SVD (OR 1.19, 95% CI 0.46-2.94, p = 0.712) when adjusting for age, blood pressure, and diabetic retinopathy.
Conclusions: Although the SVD prevalence was high, we detected no significant association between SVD and haptoglobin-genotype.
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- Contributed Indexing: Keywords: Brain MRI; Cerebral small-vessel disease; Diabetes mellitus; Haptoglobin genotype; Stroke; Type 1 diabetes
- Accession Number: 0 (Haptoglobins)
0 (Chromosomal Proteins, Non-Histone) - Publication Date: Date Created: 20230301 Date Completed: 20230501 Latest Revision: 20230524
- Publication Date: 20240628
- Accession Number: PMC10148779
- Accession Number: 10.1007/s00592-023-02059-2
- Accession Number: 36856861
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