Developmental Trajectories and Predictors of Incident Dementia among Elderly Taiwanese People: A 14-Year Longitudinal Study.

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  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238455 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-4601 (Electronic) Linking ISSN: 16604601 NLM ISO Abbreviation: Int J Environ Res Public Health Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel : MDPI, c2004-
    • Subject Terms:
      Cardiovascular Diseases*/complications ; Dementia*/psychology; Humans ; Aged ; Longitudinal Studies ; Retrospective Studies ; Risk Factors
    • Abstract:
      The aim of this study was to identify dementia trajectories and their associated predictors among elderly Taiwanese people over a 14-year period using a nationwide representative longitudinal study. This retrospective cohort study was performed using the National Health Insurance Research Database. Group-based trajectory modeling (GBTM) was used to distinguish the specific trajectory groups of incident dementia during 2000-2013. All 42,407 patients were classified by GBTM to identify the trajectory of incident dementia, which included high- ( n = 11,637, 29.0%), moderate- ( n = 19,036, 44.9%), and low-incidence ( n = 11,734, 26.1%) groups. Those diagnosed with hypertension (adjusted odds ratio [aOR] = 1.43; 95% confidence interval [CI] = 1.35-1.52), stroke (aOR = 1.45, 95% CI = 1.31-1.60), coronary heart disease (aOR = 1.29, 95% CI = 1.19-1.39), heart failure (aOR = 1.62, 95% CI = 1.36-1.93), and chronic obstructive pulmonary disease (aOR = 1.10, 95% CI = 1.02-1.18) at baseline revealed tendencies to be classified into high-incidence groups in dementia risk. The results from a 14-year longitudinal study identified three distinct trajectories of incident dementia among elderly Taiwanese people: patients with cardiovascular disease risk factors and cardiovascular disease events tended to be classified into high-incidence dementia groups. Early detection and management of these associated risk factors in the elderly may prevent or delay the deterioration of cognitive decline.
    • References:
      Alzheimers Dement (Amst). 2021 May 02;13(1):e12180. (PMID: 33969173)
      Neurology. 2020 Aug 18;95(7):e839-e846. (PMID: 32669394)
      J Aging Health. 2021 Jan;33(1-2):63-74. (PMID: 32865104)
      Innov Aging. 2020 Jan 04;4(1):igz043. (PMID: 32405541)
      Lancet Public Health. 2022 Feb;7(2):e105-e125. (PMID: 34998485)
      Int J Gen Med. 2021 Apr 21;14:1449-1455. (PMID: 33907449)
      Alzheimers Dement. 2022 Jun 16;:. (PMID: 35708183)
      Environ Int. 2016 Nov;96:75-81. (PMID: 27614945)
      Clin Geriatr Med. 2002 Aug;18(3):463-83, vii. (PMID: 12424868)
      PLoS One. 2019 Feb 25;14(2):e0212435. (PMID: 30802256)
      Pharmacoepidemiol Drug Saf. 2011 Mar;20(3):236-42. (PMID: 21351304)
      Eur Heart J. 2020 Nov 1;41(41):4024-4033. (PMID: 33022702)
      Nat Rev Cardiol. 2015 May;12(5):267-77. (PMID: 25583619)
      Int J Alzheimers Dis. 2012;2012:568382. (PMID: 22577592)
      Ther Adv Chronic Dis. 2022 Feb 2;13:20406223211063020. (PMID: 35126964)
      Drugs Aging. 2012 Oct;29(10):819-28. (PMID: 23018581)
      Annu Rev Clin Psychol. 2010;6:109-38. (PMID: 20192788)
      BMC Geriatr. 2015 Mar 10;15:23. (PMID: 25886723)
      Neurol Ther. 2022 Jun;11(2):553-569. (PMID: 35286590)
      Aging Clin Exp Res. 2021 Oct;33(10):2671-2677. (PMID: 33594647)
      Lancet. 2020 Aug 8;396(10248):413-446. (PMID: 32738937)
      Neurobiol Aging. 2012 May;33(5):1006.e25-36. (PMID: 22048124)
      Alzheimers Dement (N Y). 2021 Jul 27;7(1):e12200. (PMID: 34337138)
      Ann Clin Transl Neurol. 2018 Sep 05;5(10):1192-1199. (PMID: 30349854)
      Int Psychogeriatr. 2021 Aug;33(8):779-789. (PMID: 33213607)
      Nature. 2011 Jul 13;475(7355):S2-4. (PMID: 21760579)
      Soc Psychiatry Psychiatr Epidemiol. 2018 Nov;53(11):1149-1160. (PMID: 30182156)
      J Quant Criminol. 2010 Dec;26(4):445-453. (PMID: 21132047)
      Acta Physiol (Oxf). 2017 Apr;219(4):790-802. (PMID: 27364224)
      J Formos Med Assoc. 2015 Mar;114(3):254-9. (PMID: 24140108)
      PLoS One. 2017 Apr 12;12(4):e0175475. (PMID: 28403222)
      Can J Public Health. 2022 Jun;113(3):455-464. (PMID: 35025100)
      Hypertension. 2014 May;63(5):894-903. (PMID: 24566080)
      Annu Rev Public Health. 2019 Apr 1;40:65-84. (PMID: 30642228)
    • Contributed Indexing:
      Keywords: dementia; group-based trajectory model; longitudinal; predictors; trajectory
    • Publication Date:
      Date Created: 20230225 Date Completed: 20230228 Latest Revision: 20231119
    • Publication Date:
      20231215
    • Accession Number:
      PMC9962520
    • Accession Number:
      10.3390/ijerph20043065
    • Accession Number:
      36833763