[Alteration of pulmonary epithelial permeability by cathepsin S in chronic obstructive pulmonary disease].

Altération de la perméabilité épithéliale pulmonaire par la cathepsine S au cours de la bronchopneumopathie chronique obstructive.

Publisher: Elsevier-Masson Country of Publication: France NLM ID: 8408032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1776-2588 (Electronic) Linking ISSN: 07618425 NLM ISO Abbreviation: Rev Mal Respir Subsets: MEDLINE

Publication: <2009- > : Issy-les-Moulineaux Cedex, France : Elsevier-Masson
Original Publication: Paris ; New York : Masson, c1984-

Pulmonary Disease, Chronic Obstructive* ; Pulmonary Emphysema* ; Emphysema*/metabolism; Humans ; Lung ; Cathepsins/metabolism

Smoking is accountable for most of the chronic obstructive pulmonary disease (COPD) cases. COPD, which is characterized by the development of chronic bronchitis, could be associated with emphysema. In active smokers, there is an overexpression of cathepsin S, a cysteine protease, which participates in the development of emphysema via its elastinolytic activity. Likewise, we demonstrated that cathepsin S could degrade one or more protein constituents of cell junctions. This deleterious proteolytic activity leads to an alteration of the integrity of the lung epithelial barrier, which in turn could aggravate chronic inflammation and promote the exacerbation phases associated with infections.
(Copyright © 2023. Published by Elsevier Masson SAS.)

Keywords: Barrière épithéliale; Bronchopneumopathie chronique obstructive (BPCO); Cathepsin S; Cathepsine S; Chronic obstructive pulmonary disease (COPD); Cigarette smoke; Epithelium; Fumée de cigarette

EC 3.4.22.27 (cathepsin S)
EC 3.4.- (Cathepsins)

Date Created: 20230224 Date Completed: 20230327 Latest Revision: 20230327

20231215

10.1016/j.rmr.2023.01.015

36828678