Multifunctional two-dimensional Bi 2 Se 3 nanodiscs for anti-inflammatory therapy of inflammatory bowel diseases.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE
    • Publication Information:
      Original Publication: Kidlington, Oxford, UK : Elsevier, c2004-
    • Subject Terms:
      Inflammatory Bowel Diseases*/drug therapy ; Colitis*/prevention & control; Mice ; Animals ; Hydrogen Peroxide ; Colon ; Reactive Oxygen Species ; Anti-Inflammatory Agents/pharmacology ; Disease Models, Animal ; Dextran Sulfate/therapeutic use
    • Abstract:
      The overexpression of reactive oxygen and nitrogen species (RONS) in the colonic mucosa destroys the mucosa and its barrier, accelerating the occurrence of inflammatory bowel disease (IBD). The elimination of RONS from the inflammatory colon has proven effective in alleviating IBD. Although many nanoantioxidants have been developed, preparing robust and efficient nano-antioxidants remains challenging. Herein, by modifying bismuth selenide (Bi 2 Se 3 ) nanodiscs with polyvinylpyrrolidone (PVP), a multifunctional nanozyme based on 2D nanomaterials was developed for the treatment of IBD. By eliminating multiple RONS, such as hydroxyl radicals (•OH), superoxide anions (O 2 - • ), nitric oxide (NO), and Bi 2 Se 3 nanodiscs enhanced cellular survival after H 2 O 2 stimulation. As evidenced by colonic injury, reduced body weight, spleen index, and proinflammatory cytokine levels in mice, RONS clearance alleviated intestinal inflammation in a prevention and delay model of acute colitis. 16S rDNA amplicon sequencing reveals that Bi 2 Se 3 nanodiscs had the potential to regulate intestinal flora, increase the proportion of Firmicutes to Bacteroidetes, inhibit Proteobacteria bacteria, and restore intestinal homeostasis. This study highlights the use of Bi 2 Se 3 nanodiscs with excellent biocompatibility, multienzyme functionality, and RONS scavenging ability as treatments for IBD without apparent adverse effects. STATEMENT OF SIGNIFICANCE: RONS were efficiently scavenged by Bi 2 Se 3 nanodiscs. Bi 2 Se 3 nanodiscs could be as a promising and potentially safe theraeputic agent for IBD. The gut microbiota could be modulated by Bi 2 Se 3 nanodiscs.
      Competing Interests: Declaration of Competing Interest The authors declare no competing financial interest.
      (Copyright © 2023 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Bi(2)Se(3); Free radical scavenging; Inflammatory bowel disease; Nanozymes; Reactive oxygen species
    • Accession Number:
      BBX060AN9V (Hydrogen Peroxide)
      0 (Reactive Oxygen Species)
      0 (Anti-Inflammatory Agents)
      9042-14-2 (Dextran Sulfate)
    • Publication Date:
      Date Created: 20230222 Date Completed: 20230320 Latest Revision: 20230326
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/j.actbio.2023.02.016
    • Accession Number:
      36805534