Menu
×
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. - 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Today's Hours
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. - 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Fetal growth restriction followed by early catch-up growth impairs pancreatic islet morphology in male rats.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Jabary M;Jabary M;Jabary M; Onoda A; Onoda A; Onoda A; Kitase Y; Kitase Y; Ueda K; Ueda K; Mimatsu H; Mimatsu H; Go S; Go S; Miura R; Miura R; Tsuji M; Tsuji M; Takahashi Y; Takahashi Y; Hayakawa M; Hayakawa M; Sato Y; Sato Y
- Source:
Scientific reports [Sci Rep] 2023 Feb 15; Vol. 13 (1), pp. 2732. Date of Electronic Publication: 2023 Feb 15.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
- Publication Information: Original Publication: London : Nature Publishing Group, copyright 2011-
- Subject Terms:
- Abstract: Fetal growth restriction (FGR), followed by postnatal early catch-up growth, is associated with an increased risk of metabolic dysfunction, including type 2 diabetes in humans. This study aims to determine the effects of FGR and early catch-up growth after birth on the pathogenesis of type 2 diabetes, with particular attention to glucose tolerance, pancreatic islet morphology, and fibrosis, and to elucidate its mechanism using proteomics analysis. The FGR rat model was made by inducing mild intrauterine hypoperfusion using ameroid constrictors (ACs). On day 17 of pregnancy, ACs were affixed to the uterine and ovarian arteries bilaterally, causing a 20.9% reduction in birth weight compared to sham pups. On postnatal day 4 (P4), the pups were assigned to either the good nutrition (GN) groups with 5 pups per dam to ensure postnatal catch-up growth or poor nutrition groups with 15 pups per dam to maintain lower body weight. After weaning, all pups were fed regular chow food ad libitum (P21). Rats in both FGR groups developed glucose intolerance; however, male rats in the FGR good nutrition (FGR-GN) group also developed hypertriglyceridemia and dysmorphic pancreatic islets with fibrosis. A comprehensive and functional analysis of proteins expressed in the pancreas showed that FGR, followed by early catch-up growth, severely aggravated cell adhesion-related protein expression in male offspring. Thus, FGR and early catch-up growth caused pancreatic islet morphological abnormalities and fibrosis associated with the disturbance of cell adhesion-related protein expressions. These changes likely induce glucose intolerance and dyslipidemia in male rats.
(© 2023. The Author(s).) - References: Ann Intern Med. 2000 Aug 1;133(3):176-82. (PMID: 10906831)
Nat Protoc. 2009;4(1):44-57. (PMID: 19131956)
Ultrasound Obstet Gynecol. 2013 Oct;42(4):400-8. (PMID: 24078432)
Diabet Med. 2016 Apr;33(4):441-5. (PMID: 26112979)
J Hypertens. 2000 Jul;18(7):815-31. (PMID: 10930178)
J Clin Endocrinol Metab. 2016 Oct;101(10):3740-3746. (PMID: 27490920)
Diabetes. 2006 Jun;55(6):1625-33. (PMID: 16731824)
Horm Res. 1998;49(# Suppl 2):7-13. (PMID: 9716820)
J Endocrinol. 2017 Nov;235(2):R63-R76. (PMID: 28808079)
Int J Epidemiol. 2002 Dec;31(6):1235-9. (PMID: 12540728)
Gend Med. 2008;5 Suppl A:S121-32. (PMID: 18395678)
Metab Syndr Relat Disord. 2018 Dec;16(10):537-542. (PMID: 30204551)
Ups J Med Sci. 2016 May;121(2):155-8. (PMID: 26998806)
Biol Rev Camb Philos Soc. 2007 Feb;82(1):143-72. (PMID: 17313527)
Circulation. 2002 Mar 5;105(9):1088-92. (PMID: 11877360)
Nutr Res. 2016 Aug;36(8):855-62. (PMID: 27440540)
J Hypertens. 1996 Aug;14(8):935-41. (PMID: 8884547)
Best Pract Res Clin Obstet Gynaecol. 2004 Aug;18(4):613-23. (PMID: 15279820)
Am J Physiol Regul Integr Comp Physiol. 2009 Aug;297(2):R291-9. (PMID: 19458276)
Pediatr Res. 2013 Feb;73(2):155-62. (PMID: 23174704)
Front Endocrinol (Lausanne). 2019 Jun 20;10:274. (PMID: 31293512)
Br Med Bull. 2001;60:5-20. (PMID: 11809615)
Lancet. 1998 Jan 17;351(9097):173-7. (PMID: 9449872)
Cardiovasc Diabetol. 2016 May 03;15:73. (PMID: 27141948)
Clin Perinatol. 2000 Jun;27(2):347-61, ix. (PMID: 10863654)
Am J Med. 1981 Jan;70(1):105-15. (PMID: 7006384)
Ultrasound Obstet Gynecol. 2016 Sep;48(3):333-9. (PMID: 26909664)
Biol Reprod. 2010 Sep;83(3):325-31. (PMID: 20445129)
J Nutr. 2004 Sep;134(9):2169-72. (PMID: 15333699)
Acta Paediatr Suppl. 2004 Dec;93(446):26-33. (PMID: 15702667)
Int J Exp Diabetes Res. 2001;2(2):139-43. (PMID: 12369717)
J Nutr. 2010 Mar;140(3):662-6. (PMID: 20107142)
Diabetes. 2014 May;63(5):1672-84. (PMID: 24408314)
Am J Epidemiol. 2012 Oct 1;176 Suppl 7:S99-105. (PMID: 23035149)
Diabetes Metab Syndr Obes. 2017 Jul 06;10:285-295. (PMID: 28740412)
BMJ. 2000 Apr 8;320(7240):967-71. (PMID: 10753147)
Endocr Connect. 2020 Sep;9(9):890-902. (PMID: 33069157)
Pediatrics. 2008 Jun;121(6):e1715-22. (PMID: 18519475)
Hypertension. 2003 Mar;41(3):457-62. (PMID: 12623943)
Paediatr Perinat Epidemiol. 1997 Apr;11(2):140-51. (PMID: 9131707)
J Physiol. 2004 Dec 1;561(Pt 2):355-77. (PMID: 15459241)
Oxid Med Cell Longev. 2019 Apr 7;2019:6734836. (PMID: 31089412)
Eur J Obstet Gynecol Reprod Biol. 2003 Sep 22;110 Suppl 1:S99-107. (PMID: 12965097)
Bull World Health Organ. 1987;65(5):663-737. (PMID: 3322602)
Cell Metab. 2020 Sep 1;32(3):334-340. (PMID: 32814016)
Front Neurol. 2018 Nov 30;9:987. (PMID: 30559704)
Clin Perinatol. 1995 Jun;22(2):375-85. (PMID: 7671543)
Reprod Toxicol. 2011 Sep;32(2):205-12. (PMID: 21620955)
Eur J Clin Nutr. 1998 Jan;52 Suppl 1:S5-15. (PMID: 9511014)
Physiol Behav. 2006 Jun 30;88(3):234-43. (PMID: 16782139)
Health Psychol. 2020 Dec;39(12):1100-1108. (PMID: 33252933)
Pediatr Res. 2008 Apr;63(4):438-43. (PMID: 18356754)
Front Cell Neurosci. 2020 Jul 28;14:212. (PMID: 32848614)
Pediatr Res. 2011 Oct;70(4):339-44. (PMID: 21885936)
Aust N Z J Obstet Gynaecol. 2006 Feb;46(1):4-14. (PMID: 16441686)
N Engl J Med. 2010 Mar 25;362(12):1090-101. (PMID: 20335585)
Neonatology. 2018;114(4):285-293. (PMID: 30011395)
Nat Rev Immunol. 2011 Feb;11(2):98-107. (PMID: 21233852)
Diabetologia. 2004 Jun;47(6):1064-70. (PMID: 15156313)
Endocrinology. 2016 Dec;157(12):4782-4793. (PMID: 27754789)
Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E931-40. (PMID: 21810930)
J Physiol. 2016 Feb 15;594(4):807-23. (PMID: 26607046)
J Hypertens. 2010 Oct;28(10):2046-52. (PMID: 20616754)
Diabetes. 2001 Oct;50(10):2279-86. (PMID: 11574409)
PLoS One. 2012;7(11):e50131. (PMID: 23166830)
Proc Nutr Soc. 1997 Mar;56(1B):233-42. (PMID: 9168535)
PLoS Biol. 2020 Jul 14;18(7):e3000410. (PMID: 32663219)
Diabetes Res Clin Pract. 2014 Dec;106(3):e90-2. (PMID: 25451899)
Endocrinology. 1999 Oct;140(10):4861-73. (PMID: 10499546)
Pancreas. 1990 Sep;5(5):533-9. (PMID: 1978314)
Am J Pathol. 2014 May;184(5):1446-57. (PMID: 24631026)
J Endocrinol. 2014 Sep;222(3):G13-25. (PMID: 25056117)
Endocr Rev. 1997 Oct;18(5):646-61. (PMID: 9331546) - Publication Date: Date Created: 20230215 Date Completed: 20230217 Latest Revision: 20230329
- Publication Date: 20240628
- Accession Number: PMC9932152
- Accession Number: 10.1038/s41598-023-28584-2
- Accession Number: 36792668
- Source:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.