Clinicopathological features of peripheral odontogenic fibromas in dogs and risk factors for their laboratory diagnosis.

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  • Additional Information
    • Source:
      Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0165053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-5827 (Electronic) Linking ISSN: 00224510 NLM ISO Abbreviation: J Small Anim Pract Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford : Blackwell Scientific Publications
    • Subject Terms:
      Odontogenic Tumors*/veterinary ; Odontogenic Tumors*/pathology ; Fibroma*/veterinary ; Fibroma*/pathology ; Dog Diseases*/epidemiology; Male ; Female ; Dogs ; Animals ; Retrospective Studies ; Biopsy/veterinary ; Risk Factors
    • Abstract:
      Objectives: To explore clinicopathological features of peripheral odontogenic fibromas in dogs and risk factors for their diagnosis.
      Materials and Methods: Data of cases with a histopathological diagnosis of peripheral odontogenic fibromas were obtained from a UK-based diagnostic laboratory and retrospectively reviewed. Prevalence amongst all biopsy submissions was assessed using binomial tests and Clopper-Pearson intervals. Age at diagnosis was assessed using t-test for independent samples. Lesion location, sex, and neuter status were assessed using χ 2 and post hoc binomial tests. Breed odds ratios were calculated using univariable logistic regression modelling.
      Results: The prevalence of peripheral odontogenic fibromas amongst all biopsy submissions was 2.8% (1001 of 35,328, 95% confidence interval [CI]: 2.7 to 3.0). The mean (sd) age was 8.1 (±2.7) years. The most affected quadrant was the rostral maxilla (40.1%). The ratio of maxillary to mandibular lesions was 1.3:1 (95% CI: 1.1 to 1.5), and for cases of multiple peripheral odontogenic fibromas the ratio of maxillary to mandibular lesions was 2.4:1 (95% CI: 1.1 to 5.6). Males had 1.2 times the odds of suffering of peripheral odontogenic fibromas compared to females (odds ratio [OR]: 1.2, 95% CI: 1.1 to 1.4). Neutering was associated with an increased risk of diagnosis (OR: 1.6, 95% CI: 1.3 to 1.9). Breeds with increased odds of peripheral odontogenic fibromas compared to crossbreed dogs included boxers (OR: 3.78, 95% CI: 2.80 to 5.09), border terriers (OR: 3.21, 95% CI: 2.10 to 4.91) and Basset Hounds (OR: 3.18, 95% CI: 1.58 to 6.44). Breeds with increased odds of multiple simultaneous peripheral odontogenic fibromas compared to crossbreed dogs included: Boxers (OR: 12.02, 95% CI: 7.13 to 20.24), border terriers (OR: 5.05, 95% CI: 2.32 to 11.43) and Staffordshire Bull terriers (OR: 2.42, 95% CI: 1.33 to 4.41).
      Clinical Significance: Knowledge of clinicopathological features and at-risk breeds for peripheral odontogenic fibroma development can assist clinicians with making a diagnosis. The identification of risk factors provides targets for future research investigating peripheral odontogenic fibroma pathogenesis.
      (© 2023 British Small Animal Veterinary Association.)
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    • Publication Date:
      Date Created: 20230214 Date Completed: 20230508 Latest Revision: 20230508
    • Publication Date:
      20240829
    • Accession Number:
      10.1111/jsap.13586
    • Accession Number:
      36782367