Item request has been placed!
×
Item request cannot be made.
×
Processing Request
The roles of fungus in CNS autoimmune and neurodegeneration disorders.
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
- Additional Information
- Source:
Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
- Publication Information:
Original Publication: [Lausanne : Frontiers Research Foundation]
- Subject Terms:
- Abstract:
Fungal infection or proliferation in our body is capable of initiation of strong inflammation and immune responses that result in different consequences, including infection-trigged organ injury and inflammation-related remote organ dysfunction. Fungi associated infectious diseases have been well recognized in the clinic. However, whether fungi play an important role in non-infectious central nervous system disease is still to be elucidated. Recently, a growing amount of evidence point to a non-negligible role of peripheral fungus in triggering unique inflammation, immune response, and exacerbation of a range of non-infectious CNS disorders, including Multiple sclerosis, Neuromyelitis optica, Parkinson's disease, Alzheimer's disease, and Amyotrophic lateral sclerosis et al. In this review, we summarized the recent advances in recognizing patterns and inflammatory signaling of fungi in different subsets of immune cells, with a specific focus on its function in CNS autoimmune and neurodegeneration diseases. In conclusion, the fungus is capable of triggering unique inflammation by multiple mechanisms in the progression of a body of CNS non-infectious diseases, suggesting it serves as a key factor and critical novel target for the development of potential therapeutic strategies.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Wu, Jiang, Jiang, Pang and Zhang.)
- References:
Nat Commun. 2019 Jan 4;10(1):58. (PMID: 30610193)
J Alzheimers Dis. 2017;58(1):55-67. (PMID: 28387676)
Neural Regen Res. 2017 Mar;12(3):372-375. (PMID: 28469642)
Lancet. 2022 Oct 15;400(10360):1363-1380. (PMID: 36116464)
J Neuroimmunol. 1991 Oct;34(1):53-60. (PMID: 1894734)
Trends Immunol. 2020 Jan;41(1):61-76. (PMID: 31813764)
Front Aging Neurosci. 2019 Aug 30;11:233. (PMID: 31543810)
Neural Regen Res. 2019 Sep;14(9):1490-1493. (PMID: 31089037)
J Dermatol Sci. 2016 Aug;83(2):145-7. (PMID: 27155792)
BMC Dermatol. 2014 Mar 14;14:5. (PMID: 24628775)
Annu Rev Immunol. 2012;30:491-529. (PMID: 22224766)
Mycoses. 2016 Nov;59(11):697-704. (PMID: 27061227)
Clin Cosmet Investig Dermatol. 2017 Mar 09;10:87-92. (PMID: 28331352)
Nat Biomed Eng. 2021 Aug;5(8):830-846. (PMID: 34127820)
J Clin Invest. 2020 Aug 3;130(8):4195-4212. (PMID: 32597830)
Cell Host Microbe. 2012 May 17;11(5):425-35. (PMID: 22607796)
J Fungi (Basel). 2022 Apr 10;8(4):. (PMID: 35448617)
Neurotoxicology. 2017 Jul;61:189-212. (PMID: 27045883)
mBio. 2017 Jan 31;8(1):. (PMID: 28143979)
Brain Behav Immun. 2021 Jan;91:324-338. (PMID: 33039664)
Antioxid Redox Signal. 2009 Jul;11(7):1587-602. (PMID: 19413484)
Med Mycol. 2018 Apr 1;56(suppl_1):S10-S25. (PMID: 29538738)
Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24221-24230. (PMID: 31699814)
Alzheimers Dement. 2018 Dec;14(12):1602-1614. (PMID: 30314800)
Ann Neurol. 2017 Mar;81(3):369-382. (PMID: 28220542)
Neurol Neuroimmunol Neuroinflamm. 2020 Aug 20;7(5):. (PMID: 32820020)
Cell. 2022 Mar 3;185(5):831-846.e14. (PMID: 35176228)
Amyotroph Lateral Scler Frontotemporal Degener. 2016 Oct - Nov;17(7-8):528-534. (PMID: 27324739)
Neurobiol Dis. 2017 Dec;108:249-260. (PMID: 28888971)
J Clin Invest. 2019 Jun 10;129(7):2717-2729. (PMID: 31180338)
Neurobiol Dis. 2018 Sep;117:42-61. (PMID: 29859870)
PLoS Pathog. 2011 Oct;7(10):e1002305. (PMID: 21998592)
Nat Rev Dis Primers. 2021 May 13;7(1):33. (PMID: 33986301)
Nat Rev Neurol. 2021 Dec;17(12):759-773. (PMID: 34711906)
Cell Host Microbe. 2019 Mar 13;25(3):404-417.e6. (PMID: 30870622)
Autoimmun Rev. 2020 Oct;19(10):102647. (PMID: 32801039)
J Innate Immun. 2018;10(5-6):373-397. (PMID: 29768268)
Sci Transl Med. 2016 May 25;8(340):340ra72. (PMID: 27225182)
Trends Immunol. 2019 Dec;40(12):1071-1073. (PMID: 31735512)
J Immunol. 2012 Nov 1;189(9):4666-73. (PMID: 22993206)
Cell Mol Immunol. 2022 May;19(5):602-618. (PMID: 35079145)
PLoS One. 2013 Jun 07;8(6):e63764. (PMID: 23762233)
mBio. 2017 Nov 21;8(6):. (PMID: 29162707)
Med Mycol. 1998 Aug;36(4):189-97. (PMID: 9776834)
EMBO Mol Med. 2020 Aug 7;12(8):e11592. (PMID: 32609955)
Cell. 2021 Feb 18;184(4):1017-1031.e14. (PMID: 33548172)
Brain. 2020 Jun 1;143(6):1651-1673. (PMID: 32206784)
Hum Immunol. 2013 Sep;74(9):1080-7. (PMID: 23777933)
Aging Cell. 2021 Dec;20(12):e13522. (PMID: 34811872)
Int J Biol Sci. 2015 Apr 02;11(5):546-58. (PMID: 25892962)
Front Neurol. 2019 Jul 24;10:758. (PMID: 31396143)
J Neuroimmunol. 1999 Jul 1;98(1):57-68. (PMID: 10426363)
J Fungi (Basel). 2017 Dec 25;4(1):. (PMID: 29371497)
Microorganisms. 2017 Mar 16;5(1):. (PMID: 28300772)
Blood. 2013 Mar 28;121(13):2385-92. (PMID: 23335372)
Nat Rev Neurol. 2013 Aug;9(8):445-54. (PMID: 23857047)
Eur J Clin Microbiol Infect Dis. 2010 Sep;29(9):1139-45. (PMID: 20556470)
Acta Neurol Scand. 2010 May;121(5):309-14. (PMID: 19925532)
Brain Res Bull. 2010 Apr 29;82(1-2):4-6. (PMID: 20214953)
PLoS One. 2012;7(11):e48490. (PMID: 23139786)
Mycotoxin Res. 2018 Nov;34(4):257-268. (PMID: 30006720)
Int J Microbiol. 2012;2012:920459. (PMID: 22187561)
Nat Commun. 2020 May 8;11(1):2282. (PMID: 32385235)
Neurotox Res. 2019 May;35(4):969-980. (PMID: 30515715)
Sci Total Environ. 2022 Oct 20;844:157114. (PMID: 35787909)
Brain Behav. 2020 Mar;10(3):e01549. (PMID: 32017453)
Clin Chim Acta. 2015 Sep 20;449:23-30. (PMID: 25659291)
Nat Immunol. 2019 May;20(5):559-570. (PMID: 30996332)
EBioMedicine. 2021 Sep;71:103557. (PMID: 34455391)
Nature. 2006 Aug 10;442(7103):651-6. (PMID: 16862125)
Cold Spring Harb Perspect Med. 2014 Nov 03;5(1):a019687. (PMID: 25367974)
Cell. 2016 Dec 1;167(6):1469-1480.e12. (PMID: 27912057)
Glia. 2015 Feb;63(2):206-15. (PMID: 25142016)
Cell Host Microbe. 2016 Oct 12;20(4):527-534. (PMID: 27736647)
J Leukoc Biol. 2004 Jun;75(6):1147-55. (PMID: 14982949)
Lancet Neurol. 2012 Jun;11(6):535-44. (PMID: 22608667)
Front Aging Neurosci. 2018 May 24;10:159. (PMID: 29881346)
J Neuroimmunol. 2009 Nov 30;216(1-2):98-102. (PMID: 19800696)
Ann Neurol. 1999 May;45(5):559-67. (PMID: 10319877)
Front Neurol. 2017 Oct 16;8:535. (PMID: 29085329)
Gut. 2018 Jan;67(1):108-119. (PMID: 27802154)
J Immunol Res. 2015;2015:635052. (PMID: 25969836)
Nat Rev Immunol. 2010 Jun;10(6):387-402. (PMID: 20467426)
Curr Alzheimer Res. 2005 Oct;2(4):419-23. (PMID: 16248847)
Int J Biol Sci. 2020 Feb 10;16(7):1135-1152. (PMID: 32174790)
Science. 2016 Aug 19;353(6301):777-83. (PMID: 27540165)
Glia. 2001 Feb;33(2):131-42. (PMID: 11180510)
Neurochem Int. 2016 Oct;99:110-132. (PMID: 27346602)
Immunity. 2021 Mar 9;54(3):484-498.e8. (PMID: 33581044)
Front Microbiol. 2016 Nov 07;7:1772. (PMID: 27872620)
Mucosal Immunol. 2010 Jul;3(4):361-73. (PMID: 20445503)
J Autoimmun. 2015 Nov;64:13-25. (PMID: 26142251)
Cell. 2019 Mar 7;176(6):1340-1355.e15. (PMID: 30799037)
Science. 2019 Sep 27;365(6460):. (PMID: 31604244)
Nat Commun. 2020 Apr 20;11(1):1913. (PMID: 32312989)
Infection. 2018 Aug;46(4):443-459. (PMID: 29785613)
Nat Med. 2017 Mar;23(3):337-346. (PMID: 28112734)
Lancet Neurol. 2021 Jun;20(6):470-483. (PMID: 33930317)
PLoS Pathog. 2015 Dec 17;11(12):e1005293. (PMID: 26679537)
Nat Immunol. 2013 Apr;14(4):372-9. (PMID: 23475182)
Cytokine. 2012 Apr;58(1):112-7. (PMID: 21871816)
Toxins (Basel). 2019 Jul 26;11(8):. (PMID: 31357414)
Sci Transl Med. 2022 Jan 05;14(626):eabj0473. (PMID: 34985970)
Microbes Infect. 2016 Jan;18(1):57-67. (PMID: 26369713)
Immunol Rev. 2022 Oct;311(1):50-74. (PMID: 35672656)
EMBO Mol Med. 2018 May;10(5):. (PMID: 29661910)
Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):. (PMID: 34301894)
Signal Transduct Target Ther. 2021 Aug 6;6(1):298. (PMID: 34362877)
Prog Neurobiol. 2005 Feb;75(2):109-24. (PMID: 15784302)
Nat Commun. 2018 Feb 21;9(1):751. (PMID: 29467448)
J Neurol Sci. 2021 Mar 15;422:117325. (PMID: 33516057)
Eur J Clin Microbiol Infect Dis. 2013 Jun;32(6):795-801. (PMID: 23322279)
J Allergy Clin Immunol. 2000 Oct;106(4):723-9. (PMID: 11031343)
Sci Transl Med. 2022 Nov 30;14(673):eadc9778. (PMID: 36449599)
- Contributed Indexing:
Keywords: brain disorders; disease; fungus; multiple sclerosis; signaling
- Publication Date:
Date Created: 20230213 Date Completed: 20230214 Latest Revision: 20230217
- Publication Date:
20240829
- Accession Number:
PMC9910218
- Accession Number:
10.3389/fimmu.2022.1077335
- Accession Number:
36776399
No Comments.