Emerging Roles of RNF168 in Tumor Progression.

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  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI, c1995-
    • Subject Terms:
      DNA Repair* ; Ubiquitin-Protein Ligases*/metabolism; Humans ; Carcinogenesis/genetics ; Ubiquitination ; DNA Damage
    • Abstract:
      RING finger protein 168 (RNF168) is an E3 ubiquitin ligase with the RING finger domain. It is an important protein contributing to the DNA double-strand damage repair pathway. Recent studies have found that RNF168 is significantly implicated in the occurrence and development of various cancers. Additionally, RNF168 contributes to the drug resistance of tumor cells by enhancing their DNA repair ability or regulating the degradation of target proteins. This paper summarizes and prospects the research progress of the structure and main functions of RNF168, especially its roles and the underlying mechanisms in tumorigenesis.
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    • Grant Information:
      82173842 National Natural Science Foundation of China
    • Contributed Indexing:
      Keywords: DNA damage repair; E3 ubiquitin ligase; RING finger protein family; RNF168; cancer
    • Accession Number:
      EC 2.3.2.27 (Ubiquitin-Protein Ligases)
      EC 2.3.2.27 (RNF168 protein, human)
    • Publication Date:
      Date Created: 20230211 Date Completed: 20230214 Latest Revision: 20230214
    • Publication Date:
      20230214
    • Accession Number:
      PMC9920519
    • Accession Number:
      10.3390/molecules28031417
    • Accession Number:
      36771081