Family history, waist circumference and risk of ischemic stroke: A prospective cohort study among Chinese adults.

Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9111474 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1590-3729 (Electronic) Linking ISSN: 09394753 NLM ISO Abbreviation: Nutr Metab Cardiovasc Dis Subsets: MEDLINE

Publication: 2005- : Amsterdam : Elsevier
Original Publication: [Heidelberg] : Springer International, c1991-

Ischemic Stroke*/ethnology ; Ischemic Stroke*/etiology; Adult ; Female ; Humans ; Male ; Body Mass Index ; China/epidemiology ; East Asian People/statistics & numerical data ; Prospective Studies ; Risk Factors ; Waist Circumference ; Medical History Taking ; Family ; Middle Aged ; Aged ; Urban Population

Background and Aims: The associations between genetic factors and waist circumference (WC) with stroke risk have been evaluated in Western studies. However, evidence of this association has rarely been reported in the Chinese population. This study aimed to evaluate the association between WC and family history of stroke (FHS) with ischemic stroke (IS) risk among Chinese adults and to further explore the potential interaction of these associations.
Methods and Results: The China Kadoorie Biobank (CKB) study recruited 35,508 participants aged 30-79 years from the Qingdao urban area during 2004-2008. A total of 33,355 participants were included in study. Cox regression analysis was used to estimate the multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the independent and interactional associations between FHS and WC and IS risk. Participants with FHS had a 29% (HR = 1.29, 95% CI: 1.12-1.50) higher IS risk than those without FHS. Participants with excessive WC (85 cm for males and 80 cm for females) had a 78% (HR = 1.78, 95% CI: 1.51-2.10) higher IS risk than those with normal WC. The combined effect of FHS and excessive WC on IS was statistically significant (HR = 2.29, 95% CI: 1.84-2.86). The present study further found statistically significant multiplicative interactions of FHS and WC with IS risk (P interaction < 0.001).
Conclusion: The present study indicated that FHS and WC were significantly associated with an increased risk of IS. The association between FHS and IS was associated with excessive WC.
Competing Interests: Declaration of competing interest The authors declare no competing interests.
(Copyright © 2023 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.)

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212946/Z/18/Z United Kingdom WT_ Wellcome Trust; 29186 United Kingdom CRUK_ Cancer Research UK; MC_UU_12026/2 United Kingdom MRC_ Medical Research Council; MC_UU_00017/1 United Kingdom MRC_ Medical Research Council; MC_U137686851 United Kingdom MRC_ Medical Research Council; United Kingdom WT_ Wellcome Trust; 088158 United Kingdom WT_ Wellcome Trust; 104085 United Kingdom WT_ Wellcome Trust

Keywords: China; Family history; Ischemic stroke; Prospective study; Waist circumference

Date Created: 20230204 Date Completed: 20230419 Latest Revision: 20231003

20240628

PMC7615010

10.1016/j.numecd.2023.01.009

36739230