Compensatory mechanisms from different exercise intensities in type 2 diabetes: a secondary analysis of a 1-year randomized controlled trial.

Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5233 (Electronic) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE

Publication: Berlin : Springer Verlag
Original Publication: Berlin : Springer International, c1991-

Diabetes Mellitus, Type 2*/therapy; Humans ; Exercise ; Body Composition ; Body Weight

Aims: This investigation aimed to determine the effect of different intensities of training on non-exercise physical activity (NEPA) and estimated thermogenesis (NEAT) from a 1-year exercise randomized controlled trial (RCT) in individuals with type 2 diabetes mellitus (T2DM) on non-training days. Additionally, changes in NEPA and estimated NEAT in those who failed (low-responders) or succeeded (high-responders) in attaining exercise-derived clinically meaningful reductions in body weight (BW) and fat mass (FM) (i.e., 6% for FM and 3% for BW) was assessed.
Methods: Individuals with T2DM (n = 80) were enrolled in a RCT with three groups: resistance training combined with moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT) and a control group. Of the 80 participants, 56 (completed data) were considered for this secondary analysis. NEPA and estimated NEAT were obtained by accelerometry and body composition through dual-energy X-ray absorptiometry.
Results: After adjustments, no time*group interactions were found for estimated NEAT in the MICT (β = - 5.33, p = 0.366) and HIIT (β = - 5.70, p = 0.283), as well as for NEPA in the MICT (β = - 452.83, p = 0.833) and HIIT (β = - 2770.76, p = 0.201), when compared to controls. No compensatory changes in NEPA and estimated NEAT were observed when considering both low-responders and high-responders to FM and BW when compared to controls.
Conclusions: Both MICT and HIIT did not result in any compensatory changes in estimated NEAT and NEPA with the intervention on non-training days. Moreover, no changes in estimated NEAT and NEPA were found when categorizing our participants as low-responders and high-responders to FM and BW when compared to controls. Trial registration clinicaltrials.gov ID. NCT03144505.
(© 2023. The Author(s).)

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UIDB/00447/2020 Fundação para a Ciência e a Tecnologia; SFRH/BD/149394/2019 Fundação para a Ciência e a Tecnologia; SFRH/BD/ 85742/2012 Fundação para a Ciência e a Tecnologia; SFRH/BPD/115977/2016 Fundação para a Ciência e a Tecnologia; 2020.07856.BD Fundação para a Ciência e a Tecnologia; 2020 Fundação para a Ciência e a Tecnologia

Keywords: Compensation; Diabetes mellitus; HIIT; NEAT; NEPA; Spontaneous activity

ClinicalTrials.gov NCT03144505

Date Created: 20230202 Date Completed: 20230403 Latest Revision: 20230421

20231215

PMC10063485

10.1007/s00592-023-02038-7

36729308