Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems.

Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Original Publication: San Francisco, CA : Public Library of Science

Drug Delivery Systems*/methods ; Iodoacetic Acid*/administration & dosage ; Iodoacetic Acid*/toxicity ; Osteoarthritis*/diagnostic imaging ; Osteoarthritis*/drug therapy ; Osteoarthritis*/etiology ; Osteoarthritis*/pathology ; Matrix Metalloproteinase 8*/administration & dosage ; Matrix Metalloproteinase 8*/toxicity ; Temporomandibular Joint Disorders*/diagnostic imaging ; Temporomandibular Joint Disorders*/drug therapy ; Temporomandibular Joint Disorders*/etiology ; Temporomandibular Joint Disorders*/pathology; Animals ; Male ; Rats ; Collagenases/administration & dosage ; Collagenases/toxicity ; Disease Models, Animal ; Injections, Intra-Articular ; Pain/chemically induced ; Pain/etiology ; Rats, Wistar ; Tomography, X-Ray Computed ; Arthralgia/chemically induced ; Arthralgia/etiology

Objective: To compare two agents that can induce a rat model of temporomandibular joint osteoarthritis (TMJOA) by chemical induction: monosodium iodoacetate (MIA) and collagenase type 2 (Col-2). We wished to ascertain the best agent for assessing drug-delivery systems (DDSs).
Method: Male Wistar rats underwent intra-articular injection with MIA or Col-2. They were manipulated for 30 days. The head withdrawal threshold (HWT), immunohistological assessment, and positron emission tomography (PET) were used to evaluate the relevance of our models.
Results: For both the MIA and Col-2 groups, pain persisted for 30 days after injection. Change in the HWT showed that Col-2 elicited a strong action initially that decreased progressively. MIA had a constant action upon pain behavior. Histology of TMJ tissue from both groups showed progressive degradation of TMJ components.
Conclusions: MIA and Col-2 induced orofacial pain by their local chemical action on TMJs. However, based on a prolonged and greater sustained effect on the pain threshold, persistent histological changes, and imaging results, MIA appeared to be more suitable for creation of a rat model of TMJOA for the study of DDSs.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Barry et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

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EC 3.4.24.- (Collagenases)
WF5188V710 (Iodoacetic Acid)
EC 3.4.24.34 (Matrix Metalloproteinase 8)

Date Created: 20230131 Date Completed: 20230208 Latest Revision: 20230320

20240829

PMC9888674

10.1371/journal.pone.0281135

36719872