Two new halogenated sesquiterpene lactones from Palisada intermedia .

Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE

Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003-

Sesquiterpenes*/chemistry ; Sesquiterpenes*/isolation & purification ; Sesquiterpenes*/pharmacology ; Lactones*/chemistry ; Lactones*/pharmacology ; Lactones*/isolation & purification ; Antineoplastic Agents, Phytogenic*/chemistry ; Antineoplastic Agents, Phytogenic*/pharmacology ; Antineoplastic Agents, Phytogenic*/isolation & purification; Humans ; Molecular Structure ; Cell Line, Tumor ; Magnetic Resonance Spectroscopy ; MCF-7 Cells ; Drug Screening Assays, Antitumor ; Palmitic Acid/chemistry ; Palmitic Acid/isolation & purification

Two new sesquiterpene lactones, laurenolide A ( 1 ) and laurenolide B ( 2 ), along with six known compounds, palmitic acid ( 3 ), ( R , R )-hexahydrofarnesyl acetone ( 4 ), trans -phytol acetate ( 5 ), cholesterol ( 6 ), cholesteryl acetate ( 7 ), cholesteryl heptadecanoate ( 8 ) were isolated from Palisada intermedia . The chemical structures of all compounds were elucidated by 1D and 2D-NMR spectroscopy and HR-ESI-MS analysis as well as compared with data in the literature. The petroleum ether, chloroform, ethyl acetate, methanol extracts and compounds 1 , 2 were tested for the inhibition of two cancer cell lines MCF-7, NCI-H460 and they showed weak or none activities.

Keywords: Laurencia intermedia; Palisada intermedia; Sesquiterpene lactone; cytotoxic activities; halogenated; laurenolide A and B; snyderane

0 (Sesquiterpenes)
0 (Lactones)
0 (Antineoplastic Agents, Phytogenic)
2V16EO95H1 (Palmitic Acid)

Date Created: 20230123 Date Completed: 20240711 Latest Revision: 20240711

20240711

10.1080/14786419.2023.2171407

36688708