Relationship between early-onset stroke and triglyceride-glucose index among young Chinese adults.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101147696 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-511X (Electronic) Linking ISSN: 1476511X NLM ISO Abbreviation: Lipids Health Dis Subsets: MEDLINE
    • Publication Information:
      Original Publication: [London] : BioMed Central, 2002-
    • Subject Terms:
      Blood Glucose*/analysis ; Stroke*/epidemiology ; Triglycerides*/blood; Female ; Humans ; Male ; Age of Onset ; Biomarkers/blood ; East Asian People ; Risk Factors ; Young Adult ; China/epidemiology
    • Abstract:
      Background: The triglyceride-glucose index (TyG index), an alternative indicator of peripheral insulin resistance (IR), is associated with cardiovascular disease (CVD) in the general population. The aim of this research was to determine the correlation between early-onset stroke and the TyG index among young Chinese adults.
      Methods: Participants (age ≤ 40 years) who attended their first physical examination in Kailuan General Hospital or its 11 subsidiary hospitals between 2006 and 2012 were enrolled. The subjects were divided into four equal points according to the quartile of the TyG index, with the lowest quartile (Q1) as the reference group. A Cox proportional hazard model was employed to assess the correlation between early-onset stroke incidence and the TyG index. Restricted cubic spline analysis was further conducted to examine nonlinear associations. The TyG index was calculated as Ln [Triglyceride (TG, mg/dL) × Fasting Blood Glucose (FBG, mg/dL)/2].
      Results: Overall, 35,999 subjects met the inclusion criteria. Their mean age was 30.8 ±  5.7 years, and 77.1% of subjects were males. During a median observation period of 11 years, 281 stroke events occurred (62 hemorrhagic strokes and 219 ischemic strokes). Compared to the Q1 group (as the lowest group), subjects in groups Q2-Q4 had significantly higher risks of early-onset stroke (P < 0.05) after adjustment for relevant confounders in the Cox proportional hazards model. Similar results were consistent with ischemic stroke. However, no significant associations were observed between the risk of hemorrhage and the baseline TyG index. The restricted cubic splines revealed that the risk of stroke progressively increased with a high TyG index ≥ 8.41.
      Conclusions: The TyG index may be a major risk factor for early-onset stroke among young Chinese adults. A TyG index ≥ 8.41 can be used as an indicator for screening high-risk stroke groups.
      (© 2023. The Author(s).)
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    • Contributed Indexing:
      Keywords: Early-onset stroke; Triglyceride-glucose index; Young Chinese adults
    • Accession Number:
      0 (Biomarkers)
      0 (Blood Glucose)
      0 (Triglycerides)
    • Publication Date:
      Date Created: 20230111 Date Completed: 20230222 Latest Revision: 20240910
    • Publication Date:
      20240910
    • Accession Number:
      PMC9832803
    • Accession Number:
      10.1186/s12944-023-01773-8
    • Accession Number:
      36631854