Menu
×
West Ashley Library
Closed
Phone: (843) 766-6635
Folly Beach Library
Closed
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
Closed
Phone: (843) 805-6888
Village Library
Closed
Phone: (843) 884-9741
St. Paul's/Hollywood Library
Closed
Phone: (843) 889-3300
Otranto Road Library
Closed
Phone: (843) 572-4094
Mt. Pleasant Library
Closed
Phone: (843) 849-6161
McClellanville Library
Closed
Phone: (843) 887-3699
Keith Summey North Charleston Library
Closed
Phone: (843) 744-2489
John's Island Library
Closed
Phone: (843) 559-1945
Hurd/St. Andrews Library
Closed
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
Closed
Phone: (843) 869-2355
Dorchester Road Library
Closed
Phone: (843) 552-6466
John L. Dart Library
Closed
Phone: (843) 722-7550
Baxter-Patrick James Island
Closed
Phone: (843) 795-6679
Main Library
2 p.m. – 5 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
Closed
Phone: (843) 805-6892
Mobile Library
Closed
Phone: (843) 805-6909
Today's Hours
West Ashley Library
Closed
Phone: (843) 766-6635
Folly Beach Library
Closed
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
Closed
Phone: (843) 805-6888
Village Library
Closed
Phone: (843) 884-9741
St. Paul's/Hollywood Library
Closed
Phone: (843) 889-3300
Otranto Road Library
Closed
Phone: (843) 572-4094
Mt. Pleasant Library
Closed
Phone: (843) 849-6161
McClellanville Library
Closed
Phone: (843) 887-3699
Keith Summey North Charleston Library
Closed
Phone: (843) 744-2489
John's Island Library
Closed
Phone: (843) 559-1945
Hurd/St. Andrews Library
Closed
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
Closed
Phone: (843) 869-2355
Dorchester Road Library
Closed
Phone: (843) 552-6466
John L. Dart Library
Closed
Phone: (843) 722-7550
Baxter-Patrick James Island
Closed
Phone: (843) 795-6679
Main Library
2 p.m. – 5 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
Closed
Phone: (843) 805-6892
Mobile Library
Closed
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
A Rapid Label-Free Disposable Electrochemical Salivary Point-of-Care Sensor for SARS-CoV-2 Detection and Quantification.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Farsaeivahid N;Farsaeivahid N; Grenier C; Grenier C; Nazarian S; Nazarian S; Wang ML; Wang ML
- Source:
Sensors (Basel, Switzerland) [Sensors (Basel)] 2022 Dec 30; Vol. 23 (1). Date of Electronic Publication: 2022 Dec 30.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101204366 Publication Model: Electronic Cited Medium: Internet ISSN: 1424-8220 (Electronic) Linking ISSN: 14248220 NLM ISO Abbreviation: Sensors (Basel) Subsets: MEDLINE
- Publication Information: Original Publication: Basel, Switzerland : MDPI, c2000-
- Subject Terms:
- Abstract: The coronavirus disease 2019 (COVID-19) pandemic has created an urgent need for accurate early diagnosis and monitoring. A label-free rapid electrochemical point-of-care (POC) biosensor for SARS-CoV-2 detection in human saliva is reported here to help address the shortcomings of traditional nucleic acid amplification methods and give a quantitative assessment of the viral load to track infection status anywhere, using disposable electrochemical sensor chips. A new chemical construct of gold nanoparticles (GNp) and thionine (Th) are immobilized on carboxylic acid functionalized carbon nanotubes (SWCNT-COOH) for high-performance biosensing. The sensor uses saliva with a one-step pretreatment and simple testing procedure as an analytical medium due to the user-friendly and non-invasive nature of its procurement from patients. The sensor has a response time of 5 min with a limit of detection (LOD) reaching 200 and 500 pM for the freely suspended spike (S) protein in phosphate buffer saline (PBS) and human saliva, respectively. The sensor's performance was also proven for detecting a COVID-19 pseudovirus in an electrolyte solution with a LOD of 10 6 copies/mL. The results demonstrate that the optimized POC sensor developed in this work is a promising device for the label-free electrochemical biosensing detection of SARS-CoV-2 and different species of viruses.
- References: Biosensors (Basel). 2022 Aug 13;12(8):. (PMID: 36005033)
iScience. 2022 Apr 15;25(4):104055. (PMID: 35291265)
Res Immunol. 1994 Sep;145(7):541-52. (PMID: 7754200)
Wellcome Open Res. 2020 Jun 11;5:139. (PMID: 33748431)
Emerg Infect Dis. 2018 Oct;24(10):1964-1966. (PMID: 30226169)
Int J Infect Dis. 2021 Aug;109:118-122. (PMID: 34242764)
J Med Virol. 2020 Sep;92(9):1518-1524. (PMID: 32104917)
Anal Biochem. 2010 Mar 15;398(2):161-8. (PMID: 19962366)
Sci Rep. 2017 Nov 16;7(1):15707. (PMID: 29146948)
ACS Cent Sci. 2020 May 27;6(5):591-605. (PMID: 32382657)
Emerg Microbes Infect. 2020 Dec;9(1):382-385. (PMID: 32065055)
J Clin Virol. 2018 Apr;101:52-56. (PMID: 29427907)
Biosens Bioelectron. 2021 Jan 1;171:112686. (PMID: 33086175)
Sci Rep. 2021 Apr 27;11(1):9026. (PMID: 33907239)
Mikrochim Acta. 2022 Apr 1;189(4):168. (PMID: 35362759)
Sens Actuators Rep. 2020 Nov;2(1):100017. (PMID: 35047828)
Nat Commun. 2021 Feb 5;12(1):802. (PMID: 33547323)
Sens Actuators B Chem. 2022 Feb 15;353:131128. (PMID: 34866796)
Biosens Bioelectron. 2021 Apr 15;178:113029. (PMID: 33515985)
N Engl J Med. 2020 Sep 24;383(13):1283-1286. (PMID: 32857487)
Open Forum Infect Dis. 2017 Mar 25;4(2):ofx052. (PMID: 28616442)
Acta Pharmacol Sin. 2020 Sep;41(9):1141-1149. (PMID: 32747721)
J Neural Eng. 2021 Mar 17;18(3):. (PMID: 33578409)
Int J Mol Sci. 2021 Feb 18;22(4):. (PMID: 33670545)
Thorax. 2020 Dec;75(12):1082-1088. (PMID: 32796119)
Biosens Bioelectron. 2021 Jan 1;171:112685. (PMID: 33113383)
Rev Med Virol. 2021 Nov;31(6):e2215. (PMID: 33476080)
Phys Chem Chem Phys. 2016 Oct 19;18(41):28451-28457. (PMID: 27713936)
Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):. (PMID: 33571106)
Elife. 2020 Apr 02;9:. (PMID: 32228860)
Blood Transfus. 2007 Nov;5(4):227-40. (PMID: 19204779)
J Adv Res. 2020 Nov;26:149-159. (PMID: 32837738)
Sensors (Basel). 2008 Mar 07;8(3):1400-1458. (PMID: 27879772)
J Infect. 2020 Jul;81(1):e45-e50. (PMID: 32298676)
J Photochem Photobiol B. 2017 Sep;174:291-297. (PMID: 28818774)
J Dent Res. 2020 Dec;99(13):1435-1443. (PMID: 32936047)
Microbiol Res. 2022 Dec;265:127185. (PMID: 36113309)
Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):22727-22735. (PMID: 32868442)
J Clin Microbiol. 2020 Aug 24;58(9):. (PMID: 32636214)
ACS Nano. 2020 Apr 28;14(4):3822-3835. (PMID: 32223179)
Biosens Bioelectron. 2021 Jan 1;171:112715. (PMID: 33099241) - Contributed Indexing: Keywords: COVID-19; SARS-CoV-2 detection; biosensor; electrochemistry; point-of-care; saliva; spike protein
- Accession Number: 7440-57-5 (Gold)
0 (Nanotubes, Carbon) - Publication Date: Date Created: 20230108 Date Completed: 20230110 Latest Revision: 20230111
- Publication Date: 20231215
- Accession Number: PMC9823438
- Accession Number: 10.3390/s23010433
- Accession Number: 36617031
- Source:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.