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Sphenopalatine ganglion volumetry in episodic cluster headache: from symptom laterality to cranial autonomic symptoms.
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- Additional Information
- Source:
Publisher: BioMed Central Country of Publication: England NLM ID: 100940562 Publication Model: Electronic Cited Medium: Internet ISSN: 1129-2377 (Electronic) Linking ISSN: 11292369 NLM ISO Abbreviation: J Headache Pain Subsets: MEDLINE
- Publication Information:
Publication: [2018]- : [London, United Kingdom] : BioMed Central
Original Publication: Milano : Springer Verlag Italia, c2000-c2017.
- Subject Terms:
- Abstract:
Background: Sphenopalatine ganglion (SPG) is a peripheral structure that plays an important role in cluster headache (CH). Hence, a reliable method to measure the volume of SPG is crucial for studying the peripheral mechanism of CH. Additionally, the association between the clinical profiles and the morphology of the SPG in CH remains undetermined. This study aims to use the manual measurement of SPG volume to investigate its associations with CH, including headache laterality, cranial autonomic symptoms (CASs), presence of restlessness or agitation, and other clinical profiles.
Methods: We prospectively recruited consecutive CH patients at a tertiary medical center between April 2020 and April 2022. A total of eighty side-locked, in-bout, episodic CH patients and 40 non-headache healthy controls received 1.5 T brain MRI focusing on structural neuroimaging of the SPG. The manual measurement process for SPG was under axial and sagittal FIESTA imaging, with reference T2 weight images (sagittal and axial) for localization. The inter-observer agreement of the SPG volume (both sides of the SPG from CH patients and controls) between the two observers was calculated. In CH patients, clinical profiles and the number of CASs (range 0-5) were recorded to analyze their association with SPG volume.
Results: The inter-observer agreement between the two raters was excellent for the new SPG volumetry method at 0.88 (95% CI: 0.84-0.90, p < 0.001). The mean [SD] SPG volume was larger in CH patients than in non-headache controls (35.89 [12.94] vs. 26.13 [8.62] μL, p < 0.001). In CH patients, the SPG volume was larger on the pain side than on the non-pain side (38.87 [14.71] vs. 32.91 [12.70] μL, p < 0.001). The number of CASs was positively moderately correlated with the pain-side SPG volume (Pearson r = 0.320, p = 0.004) but not the non-pain side SPG volume (Pearson r = 0.207, p = 0.066).
Conclusions: This proof-of-concept study successfully measured the SPG volume and demonstrated its associations with symptomatology in patients with episodic CH. The direct measurement of SPG provide insights into studies on peripheral mechanism of CH.
(© 2022. The Author(s).)
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- Grant Information:
MOST 110-2314-B-075-081, 111-2314-B-075-064-MY2 Ministry of Science and Technology, Taiwan; MOST 109-2314-B-075-054 and 110-2314-B-075-041-MY3 Ministry of Science and Technology, Taiwan; MOST 109-2314-B-075-002, 110-2314-B-075-035-MY2 Ministry of Science and Technology; VGH 108-C-092, 109-C-096, and 110-C-111 Taipei Veterans General Hospital; MOST 104-2745-B-010-003, 106-2321-B-010-009, 107-2321-B-010-001, 108-2321-B-010-014 -MY2, 108-2321-B-010-001, 108-2314-B-010-023-MY3, and 110-2321-B-010-005 Ministry of Science and Technology of Taiwan
- Contributed Indexing:
Keywords: Cluster headache; Cranial autonomic symptom; Sphenopalatine ganglion
- Accession Number:
97729-66-3 (6-chloropenicillanic acid S-sulfoxide)
- Publication Date:
Date Created: 20230103 Date Completed: 20230105 Latest Revision: 20230111
- Publication Date:
20240829
- Accession Number:
PMC9809027
- Accession Number:
10.1186/s10194-022-01534-5
- Accession Number:
36597044
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