Atrophy asymmetry in hippocampal subfields in patients with Alzheimer's disease and mild cognitive impairment.

Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0043312 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1106 (Electronic) Linking ISSN: 00144819 NLM ISO Abbreviation: Exp Brain Res Subsets: MEDLINE

Original Publication: Berlin : Springer Verlag

Alzheimer Disease*/diagnostic imaging ; Cognitive Dysfunction*/diagnostic imaging ; Cognitive Dysfunction*/etiology; Humans ; Magnetic Resonance Imaging/methods ; Hippocampus/diagnostic imaging ; Hippocampus/pathology ; Atrophy/pathology

Volumetric analysis of hippocampal subfields and their asymmetry assessment recently has been useful biomarkers in neuroscience. In this study, hippocampal subfields atrophy and pattern of their asymmetry in the patient with Alzheimer's disease (AD) and mild cognitive impairment (MCI) were evaluated. MRI images of 20 AD patients, 20 MCI patients, and 20 healthy control (HC) were selected. The volumes of hippocampal subfields were extracted automatically using Freesurfer toolkit. The subfields asymmetry index (AI) and laterality ([Formula: see text]) were also evaluated. Analysis of covariance was used to compare the subfields volume between three patient groups (age and gender as covariates). We used ANOVA (P < 0.05) test for multiple comparisons with Bonferroni's post hoc correction method. Hippocampal subfields volume in AD patients were significantly lower than HC and MCI groups (P < 0.02); however, no significant difference was observed between MCI and HC groups. The asymmetry index (AI) in some subfields was significantly different between AD and MCI, as well as between AD and HC, while there was not any significant difference between MCI groups with HC. In all three patient groups, rightward laterality ([Formula: see text]) was seen in several subfields except subiculum, presubiculum, and parasubiculum, while in AD patient, rightward lateralization slightly decrease. Hippocampal subfields asymmetry can be used as a quantitative biomarker in neurocognitive disorders. In this study, it was observed that the asymmetry index of some subfields in AD is significantly different from MCI. In AD, patient rightward laterality was less MCI an HC group.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Comment in: Exp Brain Res. 2023 Sep;241(9):2205. (PMID: 37505264)

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41010 Tabriz University of Medical Sciences

Keywords: Alzheimer disease; Brain asymmetry; Brain atrophy; Brain laterality; Hippocampal subfields; Hippocampus; Mild cognitive impairment; Neuroimaging

Date Created: 20230102 Date Completed: 20230206 Latest Revision: 20230728

20240829

10.1007/s00221-022-06543-z

36593344